Severe Thrombocytopenia in 2 Thoroughbred Foals with Sepsis and Neonatal Encephalopathy

Bentz, Amy I.; Wilkins, Pamela A.; MacGillivray, K.; Barr, Bonnie S.; Palmer, Jonathan E.

doi:10.1111/j.1939-1676.2002.tb01271.x

Cited by 13 publications

(7 citation statements)

References 31 publications

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“…1,6 Although perinatal coagulopathy has been associated with neonatal infections, changes in hemostatic function associated with severe disease in critically ill neonatal foals are incompletely documented. 1,5,10,11 However, coagulopathy is a major contributor to morbidity and mortality associated with a need for intensive care in human infants, particularly those with sepsis and septic shock. [6][7][8]12,13 Coagulopathy can range from laboratory abnormalities with no clinical evidence of clotting abnormalities to fulminant disseminated intravascular coagulation.…”

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confidence: 99%

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Prospective Evaluation of Coagulation in Critically Ill Neonatal Foals

Bentz¹,

Palmer²,

Dallap³

et al. 2009

Veterinary Internal Medicne

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Background: Coagulopathy is a potentially underrecognized complication of sepsis and septic shock in critically ill neonatal foals.Hypothesis: Critically ill neonatal foals have abnormalities in coagulation that are associated with disease severity and outcome.Animals: Foals o72 hours old admitted to a neonatal intensive care unit. Methods: Prospective, observational study. Blood was collected at admission, 24, and 48 hours for platelet count, prothrombin time, activated partial thromboplastin time, antithrombin activity and concentrations of fibrin degradation products, and fibrinogen in plasma from all foals.Results: Sixty-three foals were enrolled and classified as Septic Shock (12), Septic (28), and Other (23). At least 1 abnormal value was found in 18/28 (64%) samples from the Septic Shock group, 66/85 (78%) from the Septic group, and 30/59 (51%) from the Other group (P 5 .01). Coagulopathy (3 or more abnormal values) was present in 7/28 (25%) samples in the Septic Shock group, 14/85 (16%) samples in the Septic group, and 3/59 (5%) samples in the Other group (P 5 .0028). Clinically detectable bleeding occurred in 8/12 (67%) Septic Shock cases, 11/28 (39%) Septic cases, and 3/23 (13%) Other cases (P 5 .009). Foals in Septic Shock were 12.7 times more likely to have clinical evidence of bleeding than those in the Other group (95% CI 2.3-70, P 5 .004). Treatment with fluids or plasma did not have a detectable effect on coagulation values.Conclusions and Clinical Importance: Coagulopathy commonly occurs in critically ill neonatal foals, especially those with sepsis and septic shock.

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confidence: 99%

“…1 Severe thrombocytopenia and coagulopathy occur in foals with bacteremia, sepsis, or both that resolved with directed antimicrobial therapy. 10 Coagulopathy is likely an underrecognized complication of many severe neonatal diseases. One recent report describes coagulation differences in septic, nonseptic, and control foals of 4 coagulation parameters.…”

mentioning

confidence: 99%

Prospective Evaluation of Coagulation in Critically Ill Neonatal Foals

Bentz¹,

Palmer²,

Dallap³

et al. 2009

Veterinary Internal Medicne

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“…The blood culture of the foal was negative, adequacy of passive transfer was confirmed and the foal required minimal fluid and cardiovascular support, unlike the majority of foals with sepsis (Dunkel and Corley 2015;Taylor 2015). Additionally, the magnitude of the thrombocytopenia was much greater than that previously reported for foals with septicaemia (Bentz et al 2002). In addition, the polysynovial effusions all resolved without local treatment (e.g.…”

Section: Discussionmentioning

confidence: 83%

“…Additionally, the magnitude of the thrombocytopenia was much greater than that previously reported for foals with septicaemia (Bentz et al . ). In addition, the polysynovial effusions all resolved without local treatment (e.g.…”

Section: Discussionmentioning

confidence: 97%

Thrombocytopenia, neutropenia, ulcerative dermatitis and haemarthrosis in a neonatal foal

Preez

Hughes

2017

Equine Veterinary Education

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Summary A 3‐day‐old Standardbred filly, born from a multiparous mare, was presented for assessment of limb swellings and reduced appetite. Physical examination revealed tachycardia, multifocal petechial and ecchymotic haemorrhages, stiff gait, polysynovial effusion, as well as erosions, multifocal crusting and erythema of the skin. Laboratory examinations revealed adequate transfer of passive immunity, marked thrombocytopenia, moderate neutropenia and anaemia. Aerobic bacterial blood culture was negative. Sanguineous fluid, consistent with haemarthrosis, was obtained by synoviocentesis. The foal was successfully managed with the administration of blood transfusions, an immunosuppressive regimen of corticosteroid medication, systemic antimicrobial medication and supportive care and recovered uneventfully. This report describes a neonatal foal with marked thrombocytopenia and signs of coagulopathy, neutropenia and ulcerative dermatitis consistent with a previously described syndrome. This case emphasises that alloimmune disease should be considered in neonatal foals with haemostatic disturbances or unexplained cytopenia.

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“…Septikämien infolge von Peritonitis, Pleuritis oder Verletzungen gehen ebenfalls häufig mit therapieresistentem, jedoch meist akutem Fieber, Leukozytose oder Leukopenie und Thrombozytopenie einher (Bentz et al 2002, Sellon et al 1996. In dem geschilderten Fall gab es keinen Hinweis auf eine Verletzung, die Stute zeigte keine Koliksymptome und die sonographische Untersuchung zeigte keine vermehrte, freie Flüssigkeit in Brust-und Bauchhöhle.…”

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