Severe sinus bradycardia associated with remdesivir in a child with severe SARS-COV-2 infection—reply

Abstract

Sandor-Bajusz wrote the initial reply, and Cristina Calvo reviewed the definitive manuscript. KingaAmalia Sandor-Bajusz reviewed the english language. Compliance with ethical standardsConflict of interest The corresponding author (Ana Mendez-Echevarria) is the principal investigator in La Paz Hospital of the Clinical Trial GS-US-540-5823 (Promoter: GILEAD®). The corresponding author has been parted of the Advisory Board COVID-19 of GILEAD®. The rest of the authors (Kinga-Amalia Sándor-Bajusz and Cristina Calvo) have no conflict of interest to declare.

Complications from the cardiovascular system in children who have had COVID-19

“…The specific mechanism underlying SARS-CoV-2 replication in cardiomyocytes is still debated, despite appearing similar to other coronaviruses [17]. It has recently been suggested that SARS-CoV-2 can enter myocardial cells simply by binding to ACE-2 receptors on the surface of cardiomyocytes [18]. According to the authors, patients taking ACE-1 inhibitors (ACE inhibitors) and angiotensin II receptor blockers (ARBs) have type 2 overexpression and are at high risk of cardiovascular events when infected with SARS-CoV-2.…”

Therapeutic Strategies for COVID-19 Lung Disease in Children

“…However, limited data are available regarding the occurrence of arrhythmias in children with COVID-19 and the causal correlation between RDV and bradycardia cannot be established ( 49 ). In general, electrocardiographic monitoring is suggested in all admitted children with COVID-19, especially if they are receiving RDV ( 50 ). Finally, hypersensitivity reactions are reported ( 36 ).…”