Severe Sequelae to Mold-Related Illness as Demonstrated in Two Finnish Cohorts

Abstract

The presence of toxic indoor molds with accompanying bacterial growth is clearly detrimental to human health. The pathophysiological and toxicological effects of toxins and structural components of molds and bacteria have been clarified in experiments conducted in tissue culture and animals, and there is convincing epidemiologic evidence; nonetheless their implications for human health are either ignored or denied, at least in Finland. In this communication, we describe two cohorts suffering severe sequelae to mold-related illness. One cohort is a nine-member family with pets that moved into a new house, which soon proved to be infested with pathogenic molds. The other cohort consists of 30 teachers and 50 students from a mold-infested school building. The first cohort experienced a plethora of mucosal irritation, neurological, skin, allergic, and other symptoms, with all family members ultimately developing a multiple chemical syndrome. In the second cohort, we detected a greatly elevated prevalence of autoimmune conditions and malignancies. We claim that mold-related illness exists in multiple facets; if not simply a transient mucosal irritation or even an increased risk of asthma onset or its exacerbation. We propose a scheme to explain the natural course of the mold-related illness. We recommend that future studies should combine data from, e.g., cancer, autoimmune, and endocrine disorder registers and neurological and mental health or neuropsychological registers with mold-exposed individuals being monitored for prolonged follow-up times.

The piglet mycobiome during the weaning transition: a pilot study1

“…Candidiasis of pig gastric epithelium has been documented (Smith, 1967) despite healthy appearance in piglets and Pneumocystis colonization has been associated with poor outcomes during viral infections (Kureljusic et al, 2016;Weissenbacher-Lang et al, 2016). Failure to thrive in humans has been associated with fungal infections (sometimes subclinical) (Gupta, 2014;Tuuminen and Rinne, 2017); however, the ability of fungal populations to alter piglet growth remains to be elucidated.…”

Toxicant-induced loss of tolerance for chemicals, foods, and drugs: assessing patterns of exposure behind a global phenomenon

“…Important evidence of mold-related TILT occurred when Finnish family members moved into a moisture-damaged house and subsequently developed chemical intolerance [42,43]. Initial symptoms included intense eye irritation, cough, congestion, sinus and throat infections, and shortness of breath, which flared whenever they were home.…”

Экзосомы: Механизмы Возникновения, Состав, Транспорт, Биологическая Активность, Использование В Диагностике

“…Концентрация опухолевой ДНК в моче достаточно высока -мутантный ген K-ras обнаружен во внДНК мочи у пяти из восьми больных раком поджелудочной железы и у четырех из пяти больных раком кишечника [20]. Возможность поступления ДНК в мочу из крови доказывают результаты опытов по выявлению в моче больных туберкулезом ДНК Mycobacterium tuberculosis [22,23].…”