Severe sepsis due to Mycobacterium tuberculosis following extracorporeal shock-wave lithotripsy

Chaumeron, Arnaud; Peceny, Julia K.; Rauzy, Odile Beyne; Marchou, B.; Auvergnat, J.Ch.

doi:10.1111/j.1469-0691.1998.tb00367.x

Cited by 1 publication

(2 citation statements)

References 9 publications

(8 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Sepsis is one of the most common clinical ET‐associated diseases. It has been reported that Mycobacterium tuberculosis infection was involved in septic shock with multiple organ dysfunctions in the immunocompetent host 9–15 . Survival of tuberculosis patients in intensive care units (ICU) has not ameliorated, and mortality is still high 16 .…”

Section: Introductionmentioning

confidence: 99%

“…It has been reported that Mycobacterium tuberculosis infection was involved in septic shock with multiple organ dysfunctions in the immunocompetent host. 9 , 10 , 11 , 12 , 13 , 14 , 15 Survival of tuberculosis patients in intensive care units (ICU) has not ameliorated, and mortality is still high. 16 Similarly, the potential molecular mechanism of tuberculosis sepsis was less well known.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Triad3A involved in the regulation of endotoxin tolerance and mycobactericidal activity through the NFκB‐nitric oxide pathway

Qin

Chen

et al. 2023

Immunity Inflam & Disease

View full text Add to dashboard Cite

Introduction: Sepsis is characterized by an endotoxin tolerance phenotype that occurs in the stage of infection. Persistent bacterial infection can lead to immune cell exhaustion. Triad3A, an E3 ubiquitin ligase, negatively regulates its activation by TLR4. However, the effect of Triad3A on endotoxin tolerance and bactericidal ability in the state of endotoxin tolerance remains unclear.Methods: Using single dose LPS and repeated LPS stimulated macrophage cell lines at indicated times, we investigated miR-191, Tirad3A, TRAF3, TLR4, p-P65, TNF-α, IL-1β, and iNOS expression, the effect of miR-191 on Triad3A and TRAF3, gene loss-of-function analyses, the effect of Triad3A on TLR4, p-P65, cytokine, and mycobactericidal activity in endotoxin tolerant cells infected with Mycobacterium marinum.Results: Here we found that Triad3A is involved in regulating endotoxin tolerance. Our result also displayed that miR-191 expression is downregulated in macrophages in the state of endotoxin tolerance. miR-191 can directly bind to Triad3A and TRAF3. Additionally, knockdown of Triad3A can reverse the effect of decreasing TNF-α and IL-1β in endotoxin tolerant macrophages. Furthermore, we demonstrated that the TLR4-NF-κB-NO pathway was associated with Triad3A and responsible for the killing of intracellular mycobacteria in a tuberculosis sepsis model.

show abstract

Section: Introductionmentioning

confidence: 99%