Severe reversible myocardial injury associated with aluminium phosphide toxicity: A case report and review of literature

Elabbassi, Wael; Chowdhury, Mohammed Andaleeb; Fachtartz, Arif Al Nooryani

doi:10.1016/j.jsha.2013.11.006

Cited by 32 publications

(32 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Bhasin et al demonstrated a similar pattern of global hypokinesia of the left ventricule walls in 80% of their cases. Elabbassi et al had reported normalization of echocardiographic findings in aluminium phosphide poisoning survivors by the fifth day [11]. Concerning our case, the TTE control showed a gradual improvement in the left ventricular ejection fraction by the 14th day.…”

Section: Discussionsupporting

confidence: 52%

Reversible Myocardial Injury and Intraventricular Thrombus Associated with Aluminium Phosphide Poisoning

Hangouche

Fennich

Alaika

et al. 2017

Case Reports in Cardiology

View full text Add to dashboard Cite

Aluminium phosphide (ALP) is widely used as a fumigant pesticide. In case of ALP poisoning, it is responsible for myocardial dysfunction, related to toxic myocarditis, and hemodynamic disorders. We report a case of a 28-year-old female who had intentionally ingested ALP and was admitted with cardiogenic shock. The transthoracic echocardiography (TTE) at the time of admission showed severe global myocardial hypokinesia with the presence of a giant left ventricular thrombus. Cardiovascular magnetic resonance (CMR) revealed extensive toxic myocarditis with a left ventricular systolic dysfunction. All cardiac lesions were reversible after symptomatic treatment, within 6 months. We aim, by reporting this case, to evidence the complete reversibility of cardiac injury due to aluminium phosphide poisoning documented by transthoracic echocardiography and cardiovascular magnetic resonance.

show abstract

Section: Discussionsupporting

confidence: 52%

Reversible Myocardial Injury and Intraventricular Thrombus Associated with Aluminium Phosphide Poisoning

Hangouche

Fennich

Alaika

et al. 2017

Case Reports in Cardiology

View full text Add to dashboard Cite

show abstract

“…Despite its neurotoxicity, there is not much evidence for the cardiac toxicity of this metal. Few observations were made with aluminium phosphide (Elabbassi, Chowdhury & Fachtartz ; Mohan et al . ), and aluminium acetylacetonate (Corain et al .…”

Section: Discussionmentioning

confidence: 99%

Aluminium chloride‐induced toxicity in zebrafish larvae

Antonio

Grimaldi

Ferrandino

2016

Journal of Fish Diseases

View full text Add to dashboard Cite

Embryos at shield stage and larvae at protruding mouth stage were exposed to different concentrations of aluminium chloride (AlCl ) for 72 h with the purpose to analyse their phenotype and lethality. After 24, 48 and 72 h of treatment, higher toxicity of the metal was observed on larvae with minimal lethal concentration of 0.25, 0.20 and 0.08 mm, respectively, while for embryos the corresponding values were 40, 25 and 16 mm. We observed pericardial oedema and alteration of heart rate in 50% of larvae after 48 h of exposure to 100 μm. In larvae exposed to the same concentration, there was also a neurological injury at the level of glial cells, with the number of glial fibrillary acidic protein-positive cells being significantly reduced. This study confirms the toxic nature of this metal and shows that aluminium could also interestingly represent a cardiotoxin in addition to its neurotoxic ability.

show abstract

“…In AF intoxication, the clinic findings are severe vomiting attacks, resistant hypertension, and metabolic acidosis. Through mitochondrial cytochrome C inhibition, it leads to cardiac and pulmonary toxicity [4,9]. Cardiac depression causes resistant hypertension.…”

Section: Discussionmentioning

confidence: 99%

“…Within short time after the formation of phosphine gas, the death occurs [3]. For humans, the toxic dose is 20 mg/kg, while lethal dose is 50 mg/kg [4]. Most of the deaths, which occur generally due to cardiovascular toxicity, occur within first 12-24 hours [5].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A race against time in lethal aluminum phosphide intoxication: a case report

Altıntop¹,

Kaynak²

2016

Med-Science

View full text Add to dashboard Cite

Aluminum phosphide (AP) is a condition that results in death in case of use for suicide purpose. The phosphine gas, which is released as a result of aluminum phosphide intake, has high level of toxicity. It leads to cellular level hypoxia and inhibition of oxidative phosphorylation. Aluminum phosphide intoxication may cause metabolic acidosis, arrhythmia, acute respiratory distress syndrome, and shock. High-dose intakes may lead to death within hours. 22 year-old female patient was taken to our emergency service because of the suicide attempt with 6000mg aluminum phosphide tablet. We aimed to share our experience with our aluminum phosphide intoxication, which has no known antidote and leads to rapid death in follow-up. We aim to present our experiences with our case of intoxication from aluminum phosphide, which causes high mortality after the intake. 22 year-old female patient was transferred to our hospital due to suicide attempt with 6000mg aluminum phosphide tablet. The patients have no known comorbidities, medicine use or allergic history. We believe that, in preventing the high mortality rate in aluminum phosphide intoxication, metabolic acidosis, arrhythmia, ARDS and measures against the shock and the hemodialysis in early period should be performed. Although its efficiency has not been clearly proved and its use has not entered into algorithms, the use of MgSO4 and N-Acetyl-Cysteine in supportive care is an option for such cases. Further studies and proven treatment methods are needed in AP toxicity.

show abstract

Severe reversible myocardial injury associated with aluminium phosphide toxicity: A case report and review of literature

Cited by 32 publications

References 9 publications

Reversible Myocardial Injury and Intraventricular Thrombus Associated with Aluminium Phosphide Poisoning

Reversible Myocardial Injury and Intraventricular Thrombus Associated with Aluminium Phosphide Poisoning

Aluminium chloride‐induced toxicity in zebrafish larvae

A race against time in lethal aluminum phosphide intoxication: a case report

Contact Info

Product

Resources

About