Severe Psychiatric Problems in Right Hepatic Lobe Donors for Living Donor Liver Transplantation

Trotter, James F.; Hill-Callahan, Margaret M.; Gillespie, Brenda W.; Nielsen, Carrie A.; Saab, Sammy; Shrestha, Roshan; Talamantes, M; Weinrieb, Robert M.

doi:10.1097/01.tp.0000263343.21714.3b

Cited by 91 publications

(85 citation statements)

References 13 publications

(8 reference statements)

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“…Three had severe psychiatric complications, including suicide, accidental drug overdose, and suicide attempt, despite the well-being of the recipients. Although there was no clear explanation why these donors, despite detailed screening, would be at increased risk for psychiatric problems, they suggested that donors need careful preoperative assessments and perhaps prolonged postoperative monitoring (Trotter et al, 2007).…”

Section: Living Donor Liver Transplantation (Ldlt)mentioning

confidence: 99%

Role of Liver Transplantation in Acute Liver Failure

Liou

Larson

2008

Semin Liver Dis

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Section: Living Donor Liver Transplantation (Ldlt)mentioning

confidence: 99%

Role of Liver Transplantation in Acute Liver Failure

Liou

Larson

2008

Semin Liver Dis

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“…In contrast to somatic complications, psychiatric complications of the donor are not nearly as well stud- [76]. During a median postoperative follow-up of 6 months (range: 3 days-5.6 years) 16 patients (4.1%) developed one or more psychiatric complications, including 3 severe (suicide, dead after accidental drug overdose and suicide attempts).…”

Section: Donor Outcomementioning

confidence: 93%

Hot topics in liver transplantation: Organ allocation – extended criteria donor – living donor liver transplantation

Müllhaupt¹,

Dimitroulis²,

Gerlach³

et al. 2008

Journal of Hepatology

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Liver transplantation has become the mainstay for the treatment of end-stage liver disease, hepatocellular cancer and some metabolic disorders. Its main drawback, though, is the disparity between the number of donors and the patients needing a liver graft. In this review we will discuss the recent changes regarding organ allocation, extended donor criteria, living donor liver transplantation and potential room for improvement. The gap between the number of donors and patients needing a liver graft forced the transplant community to introduce an objective model such as the modified model for end-stage liver disease (MELD) in order to obtain a transparent and fair organ allocation system. The use of extended criteria donor livers such as organs from older donors or steatotic grafts is one possibility to reduce the gap between patients on the waiting list and available donors. Finally, living donor liver transplantation has become a standard procedure in specialized centers as another possibility to reduce the donor shortage. Recent data clearly indicate that center experience is of major importance in achieving good results. Great progress has been made in recent years. However, further research is needed to improve results in the future.

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“…Die Autoren berichten jedoch auch über signifikante psychiatrische Beeinträchtigungen einiger Leberlebendspender und empfehlen eine fundierte psychiatrische Spenderevaluation und -betreuung [30].…”

Section: Spender Outcome/lebensqualitätunclassified

Living donor liver transplantation in adults

Neumann

Neuhaus

Schmeding

2010

Chirurg

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The worldwide shortage of adequate donor organs implies that living donor liver transplantation represents a valuable alternative to cadaveric transplantation. In addition to the complex surgical procedure the correct identification of eligible donors and recipients plays a decisive role in living donor liver transplantation. Donor safety must be of ultimate priority and overrules all other aspects involved. In contrast to the slightly receding numbers in Europe and North America, in recent years Asian programs have enjoyed constantly increasing living donor activity. The experience of the past 15 years has clearly demonstrated that technical challenges of both bile duct anastomosis and venous outflow of the graft significantly influence postoperative outcome. While short-term in-hospital morbidity remains increased compared to cadaveric transplantation, long-term survival of both graft and patient are comparable or even better than in deceased donor transplantation. Especially for patients expecting long waiting times under the MELD allocation system, living donor liver transplantation offers an excellent therapeutic alternative. Expanding the so-called "Milan criteria" for HCC patients with the option for living donor liver transplantation is currently being controversially debated.

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Severe Psychiatric Problems in Right Hepatic Lobe Donors for Living Donor Liver Transplantation

Abstract: Despite extensive preoperative screening, some donors experience severe psychiatric complications, including suicide, after liver donation. Psychiatric assessment and monitoring of liver donors may help to understand and prevent such tragic events.

Cited by 91 publications

References 13 publications

Role of Liver Transplantation in Acute Liver Failure

Role of Liver Transplantation in Acute Liver Failure

Hot topics in liver transplantation: Organ allocation – extended criteria donor – living donor liver transplantation

Living donor liver transplantation in adults

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