2008
DOI: 10.1210/en.2008-0990
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Severe Preeclampsia-Related Changes in Gene Expression at the Maternal-Fetal Interface Include Sialic Acid-Binding Immunoglobulin-Like Lectin-6 and Pappalysin-2

Abstract: Preeclampsia (PE), which affects 4-8% of human pregnancies, causes significant maternal and neonatal morbidity and mortality. Within the basal plate, placental cytotrophoblasts (CTBs) of fetal origin invade the uterus and extensively remodel the maternal vasculature. In PE, CTB invasion is often shallow, and vascular remodeling is rudimentary. To better understand possible causes, we conducted a global analysis of gene expression at the maternal-fetal interface in placental samples from women with PE (n = 12; … Show more

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Cited by 150 publications
(171 citation statements)
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“…26 In addition, in the current study, we revealed that the decrease of plasma levels of HSD17B1 may precede the clinical onset of PE in the second trimester, without relating to the abnormalities of angiogenesis-related factors. As HSD17B1 is a steroidogenetic enzyme HSD17B1 as an independent risk factor for preeclampsia A Ohkuchi et al catalyzing the conversion of estrone to 17b-estradiol, 27,28 the decrease of 17b-estradiol might be involved in the genesis of PE.…”
Section: Discussionsupporting
confidence: 49%
“…26 In addition, in the current study, we revealed that the decrease of plasma levels of HSD17B1 may precede the clinical onset of PE in the second trimester, without relating to the abnormalities of angiogenesis-related factors. As HSD17B1 is a steroidogenetic enzyme HSD17B1 as an independent risk factor for preeclampsia A Ohkuchi et al catalyzing the conversion of estrone to 17b-estradiol, 27,28 the decrease of 17b-estradiol might be involved in the genesis of PE.…”
Section: Discussionsupporting
confidence: 49%
“…The collective cohort size in all reports demonstrating PAPPA2 protein is increased in severe preterm PE has thus far been limited to only 30 (Nishizawa et al 2008;Winn et al 2009). Therefore, we thought it was important to provide independent confirmation of this finding.…”
Section: Discussionmentioning
confidence: 99%
“…However, the present study appears to be the first to comprehensively compare PAPPA2 immunohistochemistry between PT, PE and term samples and to observe a lack of staining in term samples. Although variable, placental PAPPA2 mRNA levels have also been reported to decline with gestation (Winn et al 2009) and PAPPA2 has been shown to be a cleavage protease for insulin-like growth factor (IGF) binding protein 5 (Wang et al 2009) bioavailability. Thus, the decline in placental PAPPA2 protein observed at term in our immunohistochemical samples is possibly a result of the decreased placental growth occurring during this phase of pregnancy.…”
Section: Discussionmentioning
confidence: 99%
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“…9 Many genes have also been identified to be differentially expressed in the placenta or in decidual tissues between women with PE and women with normal pregnancies. [10][11][12] However, it is still unknown whether such differential gene expression is causal or is secondary to the disorder.…”
Section: Introductionmentioning
confidence: 99%