Severe Preeclampsia and High Frequency of Genetic Thrombophilic Mutations

Associations between phenotypes of preeclampsia and thrombophilia

“…Although the incidence in our population was very low, it confirms the findings in other studies [12,18,20,26,32,33].…”

“…Previous cohort and case-control studies showed conflicting results [10,[18][19][20][21]24,25,27,31]. However, a systematic reviews of only prospective cohort studies [30], showed no associations.…”

“…Previous cohort and case-control studies showed conflicting results on the association between the occurrence of preeclampsia and factor V Leiden [10,12,[18][19][20][21][22][23][24][25][26][27][28]. However, reported prevalence range widely from 2% to 28%.…”

Relationship between Thrombophilic Disorders and Type of Severe Early-Onset Hypertensive Disorder of Pregnancy

“…The high prevalence of thrombophilic disorders in this study is consistent with an abundance of studies demonstrating an increased rate of thrombophilic disorders in women with preeclampsia/HELLP syndrome (8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19) or fetal growth restriction (8,13,(20)(21)(22)(23)(24) compared with controls, although available evidence is not unequivocal (34)(35)(36)(37)(38)(39)(40). Meta-analyses on the subject are equally equivocal and the strength of the association is thus not without discussion (41)(42)(43)(44).…”

“…Increased rates of thrombophilic disorders have been associated with preeclampsia/HELLP syndrome (8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19). Thrombophilic disorders have also been implicated in fetal growth restriction (8,13,(20)(21)(22)(23)(24).…”