Severe Pneumonia With Thrombocytopenia Caused By Chlamydia Psittaci: A Case And Literature Review

Abstract

Background: Severe pneumonia caused by Chlamydia psittaci is a rare infectious disease associated with living environment. The causes of thrombocytopenia were infection, leukemia, idiopathic thrombocytopenia and many other factors. The determination of platelet parameters could reflect the compensatory situation of bone marrow and provide a basis reason of thrombocytopenia identification. Case presentation: Based on the patient’s symptoms, exposure history, computerized tomography（CT）and next-generation sequencing, a preliminary diagnosis of the patient were made, at the same time other infections are excluded. We reported a case of severe pneumonia with severe thrombocytopenia caused by Chlamydia psittaci. During the treatment, he was diagnosed as parrot fever and secondary immune thrombocytopenia. Anti-infection and rising platelet with Doptelet treatment were in effect. The presence of high fever, feeling faint, gastrointestinal symptoms, images of chest CT and platelet reduction, Chlamydia psittaci might be considered as a priority reason of this case, other infections and hematology disorders excluded.Conclusion: This is the first reported case of Chlamydia psittaci-induced thrombocytopenia associated with bone marrow changes and treatment. The efficacy of mokexin in the treatment of thrombocytopenia may be further generalized.

Potential Therapeutic Candidates against Chlamydia pneumonia Discovered and Developed In Silico Using Core Proteomics and Molecular Docking and Simulation-Based Approaches

“…C. pneumonia can cause chronic infection and is associated with a range of chronic lung diseases including asthma, chronic bronchitis, and chronic obstructive pulmonary disease (COPD) [ 2 ]. Chronic diseases are described as illnesses that last a year or longer and necessitate continuing medical attention, impede everyday activities, or both [ 3 , 4 ]. C. pneumoniae has a unique ability to spread from the lungs to pulmonary disease tissues such as arteries, joints, bones, and the central nervous system via peripheral blood mononuclear cells [ 5 ].…”