Severe phimosis as a notable sequela of allogeneic stem cell transplantation in boys

Abstract

Hematopoietic SCT has improved the survival rates of patients with hematologic and metabolic disorders, as well as those with malignancy or immunodeficiency. Although various complications have been reported following allogeneic SCT, phimosis has rarely been reported, and the predisposing risk factors for phimosis have not been determined. In this study, the occurrence of severe phimosis following allogeneic SCT in boys was analyzed, and its risk factors were determined. The patients were under 15 years of age. Phimosis was observed in 32.6% of 46 patients after allogeneic SCT; 13.0% of cases required surgery. On univariate analysis, risk factors for severe phimosis included chronic GVHD and the use of a conditioning regimen including anti-thymocyte globulin (ATG). Multivariate analysis showed that chronic GVHD was an independent risk factor for severe phimosis. Thus, severe phimosis is an important complication of SCT in boys, especially in patients with chronic GVHD.

Cutaneous myeloid sarcoma of the penile foreskin

“…Phimosis is a well known manifestation of chronic graft versus host disease in male patients with hematological disease treated with allogenic bone marrow/ stem cell transplant. Suzuki et al reported phimosis in 15/46 (32.6%) uncircumcised male patients under the age of 15 years treated with allogenic stem cell transplantation (15). However, the histopathological details of the circumcision skin are not mentioned in their report.…”