This article aims to encapsulate the effect of appliances on the periodontal health of patients undergoing orthodontic treatment. While orthodontic treatment provides benefits to a wide range of intra-oral and extraoral issues starting from aesthetics to mastication, there are some major setbacks in terms of relapse if the treatment is not carried out with a proper plan. Therefore, with limitations in maintaining a desired oral hygiene, which breeds various periodontal problems, iatrogenic causes further narrow down a good prognosis which is desired at the end of an orthodontic treatment or in fact, any medical procedure. This is a review of the unnatural and natural impact of orthodontic treatment on the tissues periodontium and the treatments associated with it.