Severe paraquat poisoning. A long-term survivor

Kolilekas, Likurgos; Ghizopoulou, E.; Retsou, S.; Kourelea, S.; Hadjistavrou, C

doi:10.1016/j.rmedx.2006.03.003

Cited by 6 publications

(5 citation statements)

References 12 publications

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“…[8] reported PQ poisoning during a period of 7 years (2007–2013) in Urmia with a 46.4% mortality rate which is less than that reported in some other studies. [69] Recently, Kavousi-Gharbi et al . [10] evaluated 104 cases of PQ poisoning, with a mortality rate of 43%.…”

Section: Introductionmentioning

confidence: 99%

Clinical features, treatment, prognosis, and mortality in paraquat poisonings: A hospital-based study in Iran

et al. 2019

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Objective:The aim of the present study was to evaluate the demographics, clinical characteristics, fatal dose, the efficacy of treatments, and prognosis in paraquat (PQ) poisoning in the Kerman Province of Iran.Methods:This analytical cross-sectional study was conducted on 126 PQ poisoned patients who were referred to Afzalipour Hospital during 2006–2015. Demographic variables such as age and gender, signs and symptoms of poisoning, the estimated ingested dosage of PQ, and clinical outcome were extracted from medical records. Patients were compared and categorized into two groups considering the outcome: survivors and nonsurvivors. Patients with nonoral exposures, combined drug exposures, PQ exposures more than 24 h before the presentation, and critical underlying diseases were not included in the study.Findings:Our results indicated that the mean dose of PQ used by all patients was 2358 mg, which was reported as 1846 and 2812 mg in females and males, respectively. Moreover, the results showed that the highest mortality rate was in patients with respiratory distress, followed by oral ulceration and excess salivation. In all PQ-poisoned patients, the dose of greater than approximately 2250 mg predicted death with 86.2% specificity and 75.7% sensitivity.Conclusion:Based on the results of the present study, the mortality rate in PQ-poisoned patients depended on the dose of poison, blood sugar level, and aspartate transaminase levels. Our results suggest that these parameters have excellent prognostic value for the prediction of mortality.

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Section: Introductionmentioning

confidence: 99%

Clinical features, treatment, prognosis, and mortality in paraquat poisonings: A hospital-based study in Iran

et al. 2019

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“…It is estimated that the lethal dose of PQ in an adult human is about 30 mg/kg [14,15] or 3 -6 g of PQ ion [16,17]. A previous report showed that ingestion of > 30 mL may lead to a fatal outcome in PQ-poisoned patients [18].…”

Section: Discussionmentioning

confidence: 99%

Expressions of Wingless and Int1 (Wnt)-induced secreted protein 1 in paraquat-poisoned patients

Liu¹,

Guo²,

Song³

et al. 2017

Trop. J. Pharm Res

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“…Additionally, poisoning via other routes such as dermal or mucus contact 9,10 , injection 11 and inhalation 12 have also been reported. The estimated lethal dose in an adult person is around 30 mg/kg 13 or 3-6 g of paraquat ion 8 , which is similar to 10 to 20 ml of a 20% solution.…”

Section: Introductionmentioning

confidence: 99%

“…Paraquat is extremely toxic for humans as well as animals. Ingestion (intentional or accidental) is the most common route of poisoning 8 . Additionally, poisoning via other routes such as dermal or mucus contact 9,10 , injection 11 and inhalation 12 have also been reported.…”

Section: Introductionmentioning

confidence: 99%

Case Report: Paraquat poisoning

et al. 2022

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Paraquat (1, 1′-dimethyl-4,4′-bipyridinium) is a commonly used herbicide that is highly toxic when ingested. Ingestion of toxic doses of paraquat has serious complications on the lungs, gastrointestinal tract, kidney, liver, and other organs. Due to its inherent toxicity and the lack of a specific antidote, it has a high case fatality rate. Despite being restricted to commercially licensed users in Nepal, it is a common herbicide causing both intentional and accidental poisoning. Although there have been numerous anecdotal cases of paraquat poisoning in Nepal, no reports have been published in the literature. . We report a case of a 30-year old female, who developed gastrointestinal symptoms like vomiting, diarrhoea and odynophagia, renal and liver injury after accidental ingestion of 10ml of 20% paraquat. Symptoms and organ involvement subsided with timely and appropriate supportive management.

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Severe paraquat poisoning. A long-term survivor

Cited by 6 publications

References 12 publications

Clinical features, treatment, prognosis, and mortality in paraquat poisonings: A hospital-based study in Iran

Clinical features, treatment, prognosis, and mortality in paraquat poisonings: A hospital-based study in Iran

Expressions of Wingless and Int1 (Wnt)-induced secreted protein 1 in paraquat-poisoned patients

Case Report: Paraquat poisoning

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