Severe oxalate nephropathy in Zwartbles sheep

Abstract

On the basis of the epidemiological findings, we believe that some Zwartbles sheep may have an inherited predisposition to develop pronounced renal oxalate crystal deposition, resulting in a chronic progressive nephropathy. Primary hyperoxaluria is well recognised in human beings (Bobrowski and

Trueperella abortisuis causing abortion in pigs in Scotland

“…The indings indicated oxalateassociated nephropathy, which has previously been reported in zwartbles sheep in the UK and is believed to have a hereditary component. 4,5…”

Failure of maternal colostral antibody transfer in lambs linked to excess dietary iodine

“…Large numbers of oxalate crystals, in addition to tubular dilatation consistent with ‘drunken lamb syndrome’, were seen histologically. Congenital oxalate‐associated nephropathy was suspected, despite the young age of the lamb (Strugnell and others 2011, Barley and others 2015).…”

Deleterious AGXT Missense Variant Associated with Type 1 Primary Hyperoxaluria (PH1) in Zwartbles Sheep

“…In cattle, rare cases of neonatal oxalate nephropathy in purebred calves with no known exposure to exogenous oxalates were reported [ 4 , 5 ]. In Zwartbles sheep, severe oxalate nephropathy was previously described with suspicion of hereditary predisposition on the basis of epidemiological findings in Great Britain and Northern Ireland [ 6 , 7 ]. The observed age of onset was quite variable (three weeks to three years) but the clinical signs and histopathology were similar in all the studied cases [ 6 ].…”

“…In Zwartbles sheep, severe oxalate nephropathy was previously described with suspicion of hereditary predisposition on the basis of epidemiological findings in Great Britain and Northern Ireland [ 6 , 7 ]. The observed age of onset was quite variable (three weeks to three years) but the clinical signs and histopathology were similar in all the studied cases [ 6 ]. The prevalence of PH in sheep has not been studied prospectively, but data from the 2002–2009 period suggested that the incidence of all forms of urinary system disease in Zwartbles sheep is higher (7.2%, 13/179 submissions) compared to all other breeds (0.86%, 909/105,176 submissions) [ 6 ].…”

“…The observed age of onset was quite variable (three weeks to three years) but the clinical signs and histopathology were similar in all the studied cases [ 6 ]. The prevalence of PH in sheep has not been studied prospectively, but data from the 2002–2009 period suggested that the incidence of all forms of urinary system disease in Zwartbles sheep is higher (7.2%, 13/179 submissions) compared to all other breeds (0.86%, 909/105,176 submissions) [ 6 ]. Additionally, our own data from ovine diagnostic submissions to SRUC Veterinary services during the period January 2015–end of August 2020 indicated that lesions of PH were detected only in pedigree Zwartbles sheep, comprising 6.5% (3/46 submissions) of purebred Zwartbles sheep.…”