2017
DOI: 10.1590/0101-60830000000125
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Severe orthostatic hypotension after adding low-dose aripiprazole to clozapine

Abstract: Lin YS et al. / Arch Clin Psychiatry. 2017;44(3):84 Dear Editor, Antipsychotics can cause orthostatic hypotension (OH) by blocking adrenergic receptors 1 . OH is easily under-recognized as it can be asymptomatic. In clinical practice, combination treatment of two or more antipsychotics is common; however, little attention has been paid to OH in this scenario. Here, we presented a patient who developed severe OH after adding aripiprazole 5 mg/d to clozapine 400 mg/d.A 33-year-old man with a 15-year history o… Show more

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Cited by 4 publications
(5 citation statements)
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“…[21][22][23] It is because adverse drug reactions that are as unwanted effects of drug treatment, 24 with adrenergic receptors. 25 Furthermore, more on the dose of antipsychotic drugs or due to other physical conditions, tend to developed orthostatic hypotension. Prevention of orthostatic hypotension depends on the use of antipsychotics, 23,26 stepwise titration and doses distributed throughout the day (to minimize peak levels).…”
Section: Resultsmentioning
confidence: 99%
“…[21][22][23] It is because adverse drug reactions that are as unwanted effects of drug treatment, 24 with adrenergic receptors. 25 Furthermore, more on the dose of antipsychotic drugs or due to other physical conditions, tend to developed orthostatic hypotension. Prevention of orthostatic hypotension depends on the use of antipsychotics, 23,26 stepwise titration and doses distributed throughout the day (to minimize peak levels).…”
Section: Resultsmentioning
confidence: 99%
“…The BP lowering mechanism may be due to blocking the α1‐adrenergic receptors. Moreover, its 5‐HT2A antagonism could induce vasodilation and its 5‐HT1A agonism could produce hypotension and bradycardia (Lin, Ho, & Liang, 2017). Regarding OLA, SBP, DBP and HR significantly decreased after the first dose.…”
Section: Discussionmentioning
confidence: 99%
“…DBP decreased more in HTR2A rs6313 C allele carriers compared to T/T subjects during ARI treatment. Carriers of the wild‐type allele of HTR2A rs6313 could have induced vasodilatation, and therefore a decrease in BP (Lin et al, 2017).…”
Section: Discussionmentioning
confidence: 99%
“…The BP lowering mechanism may be due to blocking the α1-adrenergic receptors. Moreover, its 5-HT2A antagonism could induce vasodilation and its 5-HT1A agonism could produce hypotension and bradycardia (Lin et al, 2017). Regarding OLA, SBP, DBP and HR significantly decreased after the first dose.…”
Section: Discussionmentioning
confidence: 99%
“…DBP decreased more in HTR2A rs6313 C allele carriers compared to T/T subjects during ARI treatment. Carriers of the wild-type allele of HTR2A rs6313 could have induced vasodilatation, and therefore a decrease in blood pressure (Lin et al, 2017).…”
Section: Discussionmentioning
confidence: 99%