Severe Neurologic Disorders in 2 Fetuses with Zika Virus Infection, Colombia

Acosta‐Reyes, Jorge; Navarro, Édgar; Herrera, M; Goenaga, Eloina; Ospina, Martha; Parra, Édgar; Mercado, Marcela; Chaparro, Pablo; Beltrán, Mauricio; Gunturiz, María Luz; Pardo, Lissethe; Valencia, Catalina; Huertas, Sandra; Rodríguez, Jorge L.; Ruiz, Gabriel Fiol; Valencia, Diana; Haddad, Lisa; Tinker, Sarah C.; Moore, Cynthia A.; Baquero, Hernando

doi:10.3201/eid2306.161702

Cited by 26 publications

(22 citation statements)

References 15 publications

(14 reference statements)

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“…After the informed consent was signed, women were interviewed, and their medical records including periconceptional and pregnancy history, were collected. The recruitment included 884 families (3993 people) from the cities of Merida, Ticul, and Progreso de Castro in the Yucatan State, South-east Mexico [16]. Merida and its metropolitan area (≈1 million inhabitants), comprises ≈50% of the Yucatan population.…”

Section: Study Populationmentioning

confidence: 99%

“…ZIKV interferes with the neural development through decreased neural progenitor cells, arrest in neuronal migration and/or disruption of the maturation process of the fetus central nervous system (CNS) [12,13]. The congenital Zika virus syndrome (CZVS) is a pattern of congenital defects associated with ZIKV infection during the pregnancy so ZIKV pathogenicity and virulence is currently studied [14][15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

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Clinical Manifestations in Pregnant Women and Congenital Abnormalities in Fetus and Newborns during a Zika Transmission Period in South Mexico

Pavía-Ruz¹,

Contreras-Capetillo²,

Romer³

et al. 2021

Current Concepts in Zika Research

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Dengue, Chikungunya and Zika are arboviruses transmitted by Ae. aegypti with significant public health impact. In the first trimester of 2015, autochthonous Zika transmission was reported in Mexico. The state of Yucatan is an endemic region where pregnant women with acute infection and related congenital abnormalities in fetus and newborns were observed. We describe results from a cohort of pregnant women and their babies followed up in Yucatan during the first Zika transmission outbreak (2016-2018). Clinical manifestations of acute ZIKV infection, persistence of viral RNA in pregnant women, as well as congenital abnormalities were observed. In addition, we describe the phenotype of newborns from confirmed or suspected ZIKV prenatal infection.

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Section: Study Populationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Clinical Manifestations in Pregnant Women and Congenital Abnormalities in Fetus and Newborns during a Zika Transmission Period in South Mexico

Pavía-Ruz¹,

Contreras-Capetillo²,

Romer³

et al. 2021

Current Concepts in Zika Research

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“…Proliferation of infected amniotic epithelial cells could increase virus titers in amniotic fluid and enable transmission to the fetus through susceptible cells in fetal skin, gastrointestinal tract, and lung. Additionally, infected amniotic epithelial cells could amplify the viral load in amniotic fluid, increasing fetal exposure, inflammation and disease [75–77]. …”

Section: Zikv Infection Of Primary Cells and Tissues From Human Placementioning

confidence: 99%

Zika virus infection of first-trimester human placentas: utility of an explant model of replication to evaluate correlates of immune protection ex vivo

Petitt

Tabata

Puerta-Guardo

et al. 2017

Current Opinion in Virology

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The emergence of congenital Zika virus (ZIKV) disease, with its devastating effects on the fetus, has prompted development of vaccines and examination of how ZIKV breaches the maternal-fetal barrier. Infection of placental and decidual tissue explants has demonstrated cell types at the uterine-placental interface susceptible to infection and suggests routes for transmission across the placenta and amniochorionic membrane. ZIKV replicates in proliferating Hofbauer cells within chorionic villi in placentas from severe congenital infection. Explants of anchoring villi recapitulate placental architecture and early-stage development and suggest infected Hofbauer cells disseminate virus to fetal blood vessels. ZIKV infection of explants represents a surrogate human model for evaluating protection against transmission by antibodies in vaccine recipients and passive immune formulations and novel therapeutics.

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“…Available data on the performance of ZIKV detection in amniotic fluid has been limited to isolated case reports and small case series of confirmed CZS that have reported a total of 27 cases [1,[4][5][6][7][8][9][10][11].…”

mentioning

confidence: 99%