Severe mpox in patients with advanced AIDS: long-term disease and fatal outcome

Abstract

Herein, we report two cases of severe mpox in patients with advanced acquired immunodeficiency syndrome from Brazil who developed atypical lesions and prolonged illness, one of whom had a fatal outcome. Both patients experienced serious complications involving the perianal and genital regions and prolonged disease with persistent viremia.

The impact of immunosuppression on the mortality and hospitalization of Monkeypox: a systematic review and meta-analysis of the 2022 outbreak

“…There is no data about the other. - Yes Caria, 2023 [ 38 ] Brazil 1(+) Uncontrolled HIV, (CD4 + count of 173/µL) - Yes Carrubba, 2023 [ 37 ] 2 (+) Uncontrolled HIV, (CD4 + count of < 100 cells/µL) and VL > 40,000 copies per mL - Yes Menezes, 2022 [ 36 ] Brazil 1(+) Uncontrolled HIV, (CD4 count was 5 cells/µL with undetectable VL) - - Farias, 2023 [ 35 ] Brazil 1(+) Uncontrolled HIV, (CD4 + cell count < 50 cells/µL) - Yes Rajme-López, 2023 [ 17 ] Mexico 3(+) Uncontrolled HIV, (The CD4 + cell count < 200 cells/µL and the unsuppressed RNA VL) Yes, all of them are Suspected with IRIS No Warner, 2023 [ 18 ] USA 1(+) Uncontrolled HIV (the CD4 + cell count is 12 cells/µL with unsuppressed RNA VL) Yes Yes Triana-González, 2023 [ 32 ] Mexico 5 (4+) and (1-) Uncontrolled HIV, (Four had a CD4 + cell count < 200 cells/µL and an unsuppressed VL), and one was non-HIV immunocompromised - Yes Petti, 2023 [ 19 ] USA 2 (+) ...…”