Severe Metabolic Bone Disease as a Long-Term Complication of Obesity Surgery

Goldner, Whitney; O'Dorisio, Thomas M.; Dillon, Joseph S.; Mason, Edward E.

doi:10.1381/096089202321019693

Cited by 128 publications

(63 citation statements)

References 10 publications

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“…RYGB can potentially be associated to two metabolic bone disorders osteomalacia and osteoporosis. Isolated cases of osteomalacia in patients submitted to gastric bypass for morbid obesity treatment have been published in the last few years, resembling old cases of osteomalacia after gastric resection for management of peptic ulcer (23,24). While severe osteomalacia seems a latter and less frequent complication, bone loss appears to be an early effect on almost all patients submitted to RYGB (Figure 1).…”

Section: Osteoporosis and Obesity Treatmentsmentioning

confidence: 99%

Obesity, diabetes mellitus and last but not least, osteoporosis

Paula

Rosen

2010

Arq Bras Endocrinol Metab

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SummaryKnowledge about the influence of bone on intermediary metabolism corresponds to a developing area that has gained prominence. The old concept of bone and adipose tissues as inert metabolic tissues, with minor contributions to metabolic adaptations has been reconsidered in light of findings that bone is involved in the development of insulin sensitivity. Similarly adipose tissue exerts important influences on bone mass development and maintenance. Moreover, the use of drugs in the treatment of metabolic disorders such as diabetes mellitus can impact bone metabolism. These networks linking osteoporosis to obesity and diabetes mellitus have reinvigorated investigations in the pathophysiology of osteoporosis. The present review examines this aspect and calls attention to health care providers and potential treatments of skeletal disorder. Arq Bras Endocrinol Metab. 2010;54(2):150-7 Keywords Osteoporosis; obesity; diabetes mellitus; bariatric surgery; thiazolidinediones SumárioO estudo sobre a influência do tecido ósseo no metabolismo intermediário corresponde a uma área em desenvolvimento que tem ganho recente destaque. O conceito prévio de que os tecidos ósseo e adiposo seriam metabolicamente inativos foi reconsiderado à luz de estudos que mostram que metabólitos ósseos podem influenciar a sensibilidade à insulina. Da mesma forma, o tecido adiposo exerce influência importante no desenvolvimento e na manutenção da massa óssea. Além disso, o uso de drogas no tratamento de doenças metabólicas como o diabetes melito pode afetar o metabolismo ósseo. A rede de conexões existentes que ligam a osteoporose à obesidade e ao diabetes melito tem revigorado investigações sobre a fisiopatologia da osteoporose. A presente revisão analisa esse aspecto e destaca a necessidade de atenção para esses pontos por parte de serviços de saúde voltados para o atendimento de diabetes melito e da obesidade quanto ao potencial impacto sobre o tecido ósseo. Arq Bras Endocrinol Metab.

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Section: Osteoporosis and Obesity Treatmentsmentioning

confidence: 99%

Obesity, diabetes mellitus and last but not least, osteoporosis

Paula

Rosen

2010

Arq Bras Endocrinol Metab

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“…Radionuclide uptake displays more widespread patterns; these can be diffuse (a super scan) or be discrete (hotspots) [22,25]. However, these changes can frequently be mistaken for metastatic disease, limiting its use in isolation [24,26].…”

Section: Methods For Assessing Metabolic Bone Changesmentioning

confidence: 99%

“…These symptoms, once established, require aggressive therapy with calcium, phosphate and vitamin D supplementation [24,29,30]. Localised bone pain may be due to underlying lesions such as lytic lesions like osteitis fibrosa cystica or pseudofractures [26] and an increased reporting of fractures and height reduction has been seen in patients following RYGB [31].…”

Section: Changes Associated With Bariatric Surgerymentioning

confidence: 99%

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Metabolic Bone Disease and Bariatric Surgery

Sanghera¹

2013

J Gastrointest Dig Syst

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The prevalence of obesity is increasing worldwide and the past decade has witnessed an exponential rise in the number of bariatric operations performed. As a consequence, it is expected that an increasing number of patients are likely to be at risk of long term complications that may not manifest until years or decades later. Several studies have investigated the short and long-term complications of bariatric surgery but there is little available data on the longterm consequences on bone metabolism and the consequences of this after bariatric surgery. This paper reviews the current literature for further information on this clinically relevant issue.

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“…peri-menopausa (NAMS, 2006 (Goldner et al, 2002;Slater et al, 2004;Goode et al, 2004). Além disso, a baixa ingestão de vitamina D leva à menor absorção intestinal de cálcio, conforme explicado anteriormente.…”

Section: Discussionunclassified

Avaliação da ingestão de cálcio e do metabolismo ósseo e mineral em mulheres após 8 anos de Bypass Gástrico em Y de Roux

Campos¹

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Severe Metabolic Bone Disease as a Long-Term Complication of Obesity Surgery

Cited by 128 publications

References 10 publications

Obesity, diabetes mellitus and last but not least, osteoporosis

Obesity, diabetes mellitus and last but not least, osteoporosis

Metabolic Bone Disease and Bariatric Surgery

Avaliação da ingestão de cálcio e do metabolismo ósseo e mineral em mulheres após 8 anos de Bypass Gástrico em Y de Roux

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