Severe metabolic acidosis due to acetazolamide intoxication in a dog

Abstract

Case report This case report describes the clinical signs and case management of a 1‐year‐old neutered male Siberian Husky that accidentally ingested 635 mg/kg of oral acetazolamide (a carbonic anhydrase inhibitor). The dog presented with severe tachypnoea due to the development of hyperchloraemic metabolic acidosis and associated hypokalaemia that persisted for 7 days. Clinical and biochemical changes resolved with intravenous and subsequent oral supplementation of sodium bicarbonate and potassium. Complete recovery occurred within 9 days of presentation. Conclusion To the authors' knowledge, this is the first case that reports overdosage of an oral carbonic anhydrase inhibitor in a dog and subsequent recovery with adequate supplementation and supportive care.

Premedication with acetazolamide: Is its use for postoperative pain and stress control after laparoscopic ovariectomy in dogs ruled out?

“…On the other hand, acetazolamide‐induced metabolic acidosis, which reaches its maximum within 24 h in humans (Schmickl et al., 2021 ), could be a valuable issue. Overdose of acetazolamide (625 mg/kg) can produce severe hyperchloremic metabolic acidosis and hypokalaemia in dogs (Johnston et al., 2021 ). The animals included in this study received 25 mg/kg acetazolamide, and none of the animals developed any signs indicative of metabolic acidosis.…”