Severe malaria

Pinto, Marco P. Barros; Marques, G. GaiÃo

doi:10.1007/s15010-019-01371-w

Cited by 3 publications

(3 citation statements)

References 6 publications

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“…The clinical pattern of malaria, especially severe malaria, differs between children and adults. However, it is uncertain whether these differences reflect the age of affected individuals or other differences between populations in the characteristics of host, parasite, pattern of exposure or provision of health services 38 . These factors may interfere in distinguishing the cognitive effects associated with malaria between children and the elderly, however it is important to note that the impact of cognitive impairment on the child's life may be more significant, as it reflects on delays and important losses in school development, especially, that can be reflected throughout their adult life 10 – 13 , 19 – 22 , 39 .…”

Section: Discussionmentioning

confidence: 99%

Impact of Plasmodium vivax malaria on executive and cognitive functions in elderlies in the Brazilian Amazon

Pessoa

Oliveira-Pessoa

Souza

et al. 2022

Sci Rep

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The exact path leading to cognitive impairment that goes beyond malaria is unclear, but it appears to be the result of interactive factors. Time of exposure to disease and recurrences are potentially major determinant variables. Cognitive impairment is described mainly in children, rarely in adults. The disease in high endemic areas usually does not affect elderlies, because of acquired immunity over time. However, this population is relatively more frequently sick in lower endemic areas, such as in the Amazon. This study assessed the effect of Plasmodium vivax malaria on the executive and cognitive functions of elderlies, in the Brazilian Amazon. A cohort study was conducted to evaluate executive and cognitive functions one week (T0), two months (T2) and eight months (T8) after the malaria episode. Mini-Mental State Examination (MMSE), Beck Depression Inventory II (BDI-II), Clock Drawing Test (CDT), Wechsler adult intelligence scale (WAIS-III), and Wisconsin Card Sorting Test (WCST) were used to assess executive and cognitive functions. One hundred-forty elderlies were enrolled (70 with P. vivax malaria and 70 without malaria). P. vivax malaria was associated with impairment of the executive and cognitive functions in elderlies for up to 8 months after acute P. vivax malaria. Prior history of malaria, recurrences and higher parasitemia were independently associated with various surrogates of executive and cognitive impairment. With the increase in life expectancy, elderlies living in malaria endemic areas will deserve more attention from health authorities, to guarantee improvement of their quality of life in the tropics.

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Section: Discussionmentioning

confidence: 99%

Impact of Plasmodium vivax malaria on executive and cognitive functions in elderlies in the Brazilian Amazon

Pessoa

Oliveira-Pessoa

Souza

et al. 2022

Sci Rep

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“…The outcome and candidate predictor cut-off points were selected according to WHO classifications for severe metabolic acidosis and kidney injury in children with severe malaria [ 29 ]. Accordingly, severe metabolic acidosis was defined as a base excess of less than 8 mmol/l [ 29 ]. This cut-off for base excess has also been used in studies in similar settings [ 14 , 20 ].…”

Section: Methodsmentioning

confidence: 99%

“…This cut-off for base excess has also been used in studies in similar settings [ 14 , 20 ]. Kidney injury was assessed using uraemia, defined as a blood urea nitrogen (BUN) of more than 20 mg/dl [ 29 ]. Candidate predictors for each outcome were selected based on WHO signs of severe malaria and variables described in literature to be associated with each outcome.…”

Section: Methodsmentioning

confidence: 99%

Identifying prognostic factors of severe metabolic acidosis and uraemia in African children with severe falciparum malaria: a secondary analysis of a randomized trial

Mzumara

Leopold

Marsh

et al. 2021

Malar J

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Background Severe metabolic acidosis and acute kidney injury are major causes of mortality in children with severe malaria but are often underdiagnosed in low resource settings. Methods A retrospective analysis of the ‘Artesunate versus quinine in the treatment of severe falciparum malaria in African children’ (AQUAMAT) trial was conducted to identify clinical features of severe metabolic acidosis and uraemia in 5425 children from nine African countries. Separate models were fitted for uraemia and severe metabolic acidosis. Separate univariable and multivariable logistic regression were performed to identify prognostic factors for severe metabolic acidosis and uraemia. Both analyses adjusted for the trial arm. A forward selection approach was used for model building of the logistic models and a threshold of 5% statistical significance was used for inclusion of variables into the final logistic model. Model performance was assessed through calibration, discrimination, and internal validation with bootstrapping. Results There were 2296 children identified with severe metabolic acidosis and 1110 with uraemia. Prognostic features of severe metabolic acidosis among them were deep breathing (OR: 3.94, CI 2.51–6.2), hypoglycaemia (OR: 5.16, CI 2.74–9.75), coma (OR: 1.72 CI 1.17–2.51), respiratory distress (OR: 1.46, CI 1.02–2.1) and prostration (OR: 1.88 CI 1.35–2.59). Features associated with uraemia were coma (3.18, CI 2.36–4.27), Prostration (OR: 1.78 CI 1.37–2.30), decompensated shock (OR: 1.89, CI 1.31–2.74), black water fever (CI 1.58. CI 1.09–2.27), jaundice (OR: 3.46 CI 2.21–5.43), severe anaemia (OR: 1.77, CI 1.36–2.29) and hypoglycaemia (OR: 2.77, CI 2.22–3.46) Conclusion Clinical and laboratory parameters representing contributors and consequences of severe metabolic acidosis and uraemia were independently associated with these outcomes. The model can be useful for identifying patients at high risk of these complications where laboratory assessments are not routinely available.

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Reading the epitranscriptome of the human malaria parasite

Govindaraju,

Rajavelu

2024

Biomedical Journal

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Severe malaria

Cited by 3 publications

References 6 publications

Impact of Plasmodium vivax malaria on executive and cognitive functions in elderlies in the Brazilian Amazon

Impact of Plasmodium vivax malaria on executive and cognitive functions in elderlies in the Brazilian Amazon

Identifying prognostic factors of severe metabolic acidosis and uraemia in African children with severe falciparum malaria: a secondary analysis of a randomized trial

Reading the epitranscriptome of the human malaria parasite

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