Severe Malaria: A Case of a Significant Rapid Rise in the Parasite Level

Atere, Muhammed; Muzangwa, Lloyd; Kenne, Foma Munoh; Hanna, Cherry; Saverimuttu, Jessie; Kopetz, Virginia

doi:10.1155/2020/5206186

Cited by 2 publications

(2 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Plasmodium falciparum (P. falciparum) is the most dangerous species to human life. [5][6][7][8] Despite the availability of several antimalarial drugs, the emergence of drug resistance poses a significant threat to human existence. 9,10 Moreover, affordable treatment and low production cost are necessary in view of the economic status of the most affected people.…”

Section: Meomentioning

confidence: 99%

Development of a Practical Synthetic Method for Clinical Candidate 3-(2-{3-[(2,4-Diamino-6-ethylpyrimidin-5-yl)oxy]propoxy} phenyl)propanoic acid (P218) and Its Hydroxylated Metabolites

Srimongkolpithak,

Vorasin,

Phumjan

et al. 2023

Synthesis

View full text Add to dashboard Cite

Abstract3-(2-{3-[(2,4-Diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)propanoic acid, known as P218, has demonstrated great potency and safety in preclinical and human studies. However, the previous synthetic methods for P218 gave low yields and required hazardous reagents and challenging procedures. In this study, we have successfully developed a decagram-scale synthetic route for P218 with practical and scalable methods for large-scale production. Furthermore, this is also a first report of a novel synthetic approach for P218-OH, a hydroxylated metabolite of P218, by modification of our discovery route. Our synthetic procedures for P218 and P218-OH are a significant advancement in drug development processes, including manufacturing processes and drug metabolism studies.

show abstract

Section: Meomentioning

confidence: 99%

Development of a Practical Synthetic Method for Clinical Candidate 3-(2-{3-[(2,4-Diamino-6-ethylpyrimidin-5-yl)oxy]propoxy} phenyl)propanoic acid (P218) and Its Hydroxylated Metabolites

Srimongkolpithak,

Vorasin,

Phumjan

et al. 2023

Synthesis

View full text Add to dashboard Cite

show abstract

“…This was explicitly achieved by examining the association between malaria incidences and the academic activities on campus. [21,22,23,24,25]…”

Section: Table 1: Summary Data Of the Clinical Presentation Of Malari...mentioning

confidence: 99%

Investigating the epidemiological factors responsible for malaria transmission dynamics

Adegbite

Edeki

Isewon

et al. 2022

IOP Conf. Ser.: Earth Environ. Sci.

View full text Add to dashboard Cite

Despite concerted efforts by the World Health Organization (WHO) to control malaria, it is still being diagnosed in patients visiting hospitals in Tropical Countries of the World. Hence, this study investigated the risk factors responsible for malaria transmission dynamics through a hospital case study. Data of patients that presented with malaria from June 2019 to December 2020 were acquired from Covenant University Medical Centre in Ota, South West Nigeria. Descriptive statistical analyses were carried out so as to examine the factors associated with malaria incidence rate such as age, gender and travel history using the R programming platform. 14% of the total outpatient visits from June 2019 to December 2020 presented with malaria. Furthermore, the mean of the ages of those that presented with malaria, was 23.10 whereas the median of their ages was 22.0. Out of the total malaria cases, 57.7% were males whereas 42.3% were females. Results also showed that there was a significant positive correlation between malaria and travel. In conclusion, it is recommended that malaria control policy formulators should focus on the most vulnerable group of individuals as identified in this study. Further, more efforts should be geared towards curbing malaria importation as a result of human travel, by the different health authorities across the globe.

show abstract

Severe Malaria: A Case of a Significant Rapid Rise in the Parasite Level

Cited by 2 publications

References 11 publications

Development of a Practical Synthetic Method for Clinical Candidate 3-(2-{3-[(2,4-Diamino-6-ethylpyrimidin-5-yl)oxy]propoxy} phenyl)propanoic acid (P218) and Its Hydroxylated Metabolites

Development of a Practical Synthetic Method for Clinical Candidate 3-(2-{3-[(2,4-Diamino-6-ethylpyrimidin-5-yl)oxy]propoxy} phenyl)propanoic acid (P218) and Its Hydroxylated Metabolites

Investigating the epidemiological factors responsible for malaria transmission dynamics

Contact Info

Product

Resources

About