Severe Loss of Clinical Attachment Level: An Independent Association With Low Hip Bone Mineral Density in Postmenopausal Females

Gondim, Valéria; Aun, Juliana Cleaver; Fukuda, Cassia Tiemi; Takayama, Liliam; Latorre, Maria do Rosário Dias de Oliveira; Pannuti, Cláudio Mendes; Pereira, Rosa Maria Rodrigues; Romito, Giuseppe Alexandre

doi:10.1902/jop.2012.120090

Cited by 20 publications

(18 citation statements)

References 44 publications

(97 reference statements)

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“…Ronderos et al (2000) and Tezal et al (2000) showed significant association between CAL and femoral neck BMD. And, recently, a study has reported that severe CAL was associated with low femoral neck BMD in Brazilian post-menopausal females (Gondim et al 2012). On the other hand, Taguchi et al (2005) reported that self-reported periodontal status was related to lumbar spine BMD, but was not significantly associated with femoral neck BMD in post-menopausal women, and this result is in agreement with this study.…”

Section: Discussionmentioning

confidence: 98%

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The association between periodontal disease, tooth loss and bone mineral density in a Korean population

Tak

Shin

Kweon

et al. 2014

J Clinic Periodontology

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Section: Discussionmentioning

confidence: 98%

“…And, recently, a study has reported that severe CAL was associated with low femoral neck BMD in Brazilian post‐menopausal females (Gondim et al. ). On the other hand, Taguchi et al.…”

Section: Discussionmentioning

confidence: 99%

The association between periodontal disease, tooth loss and bone mineral density in a Korean population

Tak

Shin

Kweon

et al. 2014

J Clinic Periodontology

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“…Although there is no consensus today, several clinical studies suggest an association between osteoporosis and oral bone loss . Recent studies reported in women an association between osteoporosis and tooth loss, indicating that low femoral BMD and T ‐score were associated with fewer remaining teeth . In addition, low BMD and bone stiffness were associated with low number of teeth in women but not in men .…”

Section: Discussionmentioning

confidence: 99%

Respective role of membrane and nuclear estrogen receptor (ER) α in the mandible of growing mice: Implications for ERα modulation

Vinel

Coudert

Buscato

et al. 2018

Journal of Bone and Mineral Research

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Estrogens play an important role in bone growth and maturation as well as in the regulation of bone turnover in adults. Although the effects of 17β-estradiol (E2) are well documented in long bones and vertebrae, little is known regarding its action in the mandible. E2 actions could be mediated by estrogen receptor (ER) α or β. ERs act primarily as transcriptional factors through two activation functions (AFs), AF1 and AF2, but they can also elicit membrane-initiated steroid signaling (MISS). The aim of the present study was to define ER pathways involved in E2 effects on mandibular bone. Using mice models targeting ERβ or ERα, we first show that E2 effects on mandibular bone are mediated by ERα and do not require ERβ. Second, we show that nuclear ERαAF2 is absolutely required for all the actions of E2 on mandibular bone. Third, inactivation of ERαMISS partially reduced the E2 response on bone thickness and volume, whereas there was no significant impact on bone mineral density. Altogether, these results show that both nuclear and membrane ERα are requested to mediate full estrogen effects in the mandible of growing mice. Finally, selective activation of ERαMISS is able to exert an effect on alveolar bone but not on the cortical compartment, contrary to its protective action on femoral cortical bone. To conclude, these results highlight similarities but also specificities between effects of estrogen in long bones and in the mandible that could be of interest in therapeutic approaches to treat bone mass reduction. © 2018 American Society for Bone and Mineral Research.

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“…6,[9][10][11][12][13] However, due to the limited availability and cost implications of DXA devices in some regions, the diagnosis of bone disorders may be delayed until the clinical symptoms appear.…”

Section: Introductionmentioning

confidence: 99%

Radiodensitometric and DXA analyses for the measurement of bone mineral density after systemic alendronate therapy

Lucisano

Filho

Morse³

et al. 2013

Braz. oral res.

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Precise techniques for the measurement of maxillary bone mineral density (BMD) are useful for the early diagnosis of systemic diseases. The aim of this study was to compare in vivo the efficacy of dualenergy x-ray absorptiometry (DXA) and radiographic densitometry for the measurement of BMD after systemic administration of sodium alendronate. Wistar rats were randomly allocated to a control group (n = 5), which received distilled water, and a sodium alendronate group (n = 8), which received two doses of chemically pure sodium alendronate (1 mg/ kg) per week. After 8 weeks, the animals were euthanized, the tibias were removed, and the BMD of the proximal tibial metaphysis was analyzed radiographically and by DXA. The data were subjected to statistical analysis by the Kruskal-Wallis test at a significance level of 5%. Both of the techniques revealed that the alendronate-treated group had a significantly higher BMD (p < 0.05) than the control group after 8 weeks of treatment. Comparing the groups with and without alendronate therapy revealed increases of 14.9% and 29.6% in BMD, as detected radiographically and by DXA, respectively. In conclusion, both of the methods were able to detect an increase in BMD of the proximal tibial metaphysis after alendronate therapy.

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Severe Loss of Clinical Attachment Level: An Independent Association With Low Hip Bone Mineral Density in Postmenopausal Females

Cited by 20 publications

References 44 publications

The association between periodontal disease, tooth loss and bone mineral density in a Korean population

The association between periodontal disease, tooth loss and bone mineral density in a Korean population

Respective role of membrane and nuclear estrogen receptor (ER) α in the mandible of growing mice: Implications for ERα modulation

Radiodensitometric and DXA analyses for the measurement of bone mineral density after systemic alendronate therapy

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