Severe leptospirosis in a patient with positive serological test for spotted fever rickettsiosis

Harada, Yukinori; Hayashi, Minato

doi:10.1136/bcr-2018-226514

Cited by 2 publications

(2 citation statements)

References 11 publications

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“…The concomitant seroprevalent and seroincident findings provide evidence of individuals in Urabá, Colombia, who have been exposed to both microorganisms without developing overt clinical disease or being diagnosed. Our result carries important public health implications, as clinical case reports have indicated that individuals susceptible to concurrent infections by rickettsioses and leptospirosis may experience more severe clinical manifestations and potentially fatal outcomes( 18 , 22 ).…”

Section: Discussionmentioning

confidence: 81%

Eco-epidemiological study of seropositivity against Rickettsia and Leptospira agents in rural areas of Urabá, Colombia.

Torres-Bustamante,

Cantillo-Barraza,

et al. 2024

Preprint

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Rickettsioses and leptospirosis are infectious diseases that are often underdiagnosed due to a lack of knowledge about their epidemiology, pathophysiology, diagnosis, management, among others. Objetive: to characterize the seroprevalence and seroincidence of both Rickettsia and Leptospira agents and determine the risk factors for these outcomes in rural areas of Urabá, Antioquia. Methods: a secondary data analysis using information on Rickettsia and Leptospira exposure from a prior prospective study that explored sociocultural and ecological aspects of Rickettsia infection in rural Urabá, Colombia. A multinomial mixed logistic regression model was employed to analyze factors linked to seroprevalent cases of Rickettsia, Leptospira and both, along with descriptive analyses of seroincident cases. Results: the concomitant seroprevalence against Rickettsiaand Leptospira was 9.38% [95%CI 6.08%-13.37%] (56/597). The factors associated with this seroprevalence were age (ORa= 1.02 [95%CI 1.007–1.03]), male gender (ORa= 3.06 [95%CI 1.75–5.37]), fever history (ORa= 1.71 [95%CI 1.06–2.77]) the presence of breeding pigs (ORa= 2.29 [95%CI 1.36–3.88]), peridomicile yucca crops(ORa= 2.5 [95%CI 1.1–5.62]), and deforestation practices(ORa= 1.74 [95%CI 1.06–2.87]). The concomitant seroincidence against Rickettsia and Leptospira was 1.09% (3/274) [95%CI 0.29%-4.05%], three cases were female, with a median age of 31.83 years-old (IQR 8.69–56.99). At the household level, all the seroincident cases had households built partially or totally with soil floors, wooden walls, and zinc roofs. Two seroincident cases described the presence of equines, canines, and domestic chickens in intra or peri-domicile. Finally, two cases were exposed to synanthropic rodents, and one case to tick infestation. Conclusion: there is evidence of seroprevalent and seroincident cases of seropositivity against both Rickettsia and Leptospira in rural areas of Urabá, Colombia. These findings can help improve public health surveillance systems in preventing, detecting, and attending to the different clinical cases caused by these pathogens.

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Section: Discussionmentioning

confidence: 81%

Eco-epidemiological study of seropositivity against Rickettsia and Leptospira agents in rural areas of Urabá, Colombia.

Torres-Bustamante,

Cantillo-Barraza,

et al. 2024

Preprint

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“…We also observed Rickettsia spp. in confirmed leptospirosis cases; this coinfection has been associated with severe leptospirosis [ 75 ].…”

Section: Discussionmentioning

confidence: 99%

Fatal acute undifferentiated febrile illness among clinically suspected leptospirosis cases in Colombia, 2016–2019

Parra Barrera,

Reales-González,

Salas

et al. 2023

PLoS Negl Trop Dis

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Background Acute undifferentiated febrile illness is a common challenge for clinicians, especially in tropical and subtropical countries. Incorrect or delayed diagnosis of febrile patients may result in medical complications or preventable deaths. Common causes of acute undifferentiated febrile illness in Colombia include leptospirosis, rickettsioses, dengue fever, malaria, chikungunya, and Zika virus infection. In this study, we described the acute undifferentiated febrile illness in postmortem patients reported as suspected cases of leptospirosis through the national leptospirosis surveillance in Colombia, 2016–2019. Methodology/principal findings We retrospectively analyze human fresh and formalin-fixed tissue samples from fatal suspected leptospirosis cases reported by the Public Health Laboratories in Colombia. Leptospirosis confirmation was made by immunohistochemistry, real-time polymerase chain reaction (PCR) in the tissue samples. In some cases, the serum sample was used for confirmation by Microagglutination test (MAT). Simultaneously, tissue samples were tested by PCR for the most common viral (dengue, Zika, and chikungunya), bacterial (Brucella spp., and Rickettsia spp.), and parasitic (malaria). Fresh tissue samples from 92 fatal suspected leptospirosis cases were reported to the National Reference Laboratory from 22/32 departments in Colombia. We confirmed leptospirosis in 27% (25/92) of cases. Other pathogens identified by real-time PCR were Brucella spp. (10.9%), Rickettsia spp. (14.1%), and dengue (2.2%). Dengue (6.9%), hepatitis (3.5%), and Yellow Fever cases (2.2%) were detected by the pathology. All patients were negative for chikungunya and Plasmodium spp. Most cases were classified as undifferentiated febrile illnesses (45.7%; 42/92). Conclusions/Significance This study underscores the importance of early and accurate recognition of leptospirosis to prevent mortalities. Moreover, it draws attention to the existence of other febrile syndromes in Colombia, including rickettsiosis and brucellosis, that currently lack sufficient human surveillance and regular reporting. Expanding laboratory surveillance to include viruses such as Hantavirus, Mayaro virus, Oropouche virus, and West Nile virus is crucial.

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Severe leptospirosis in a patient with positive serological test for spotted fever rickettsiosis

Cited by 2 publications

References 11 publications

Eco-epidemiological study of seropositivity against Rickettsia and Leptospira agents in rural areas of Urabá, Colombia.

Eco-epidemiological study of seropositivity against Rickettsia and Leptospira agents in rural areas of Urabá, Colombia.

Fatal acute undifferentiated febrile illness among clinically suspected leptospirosis cases in Colombia, 2016–2019

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