Severe lactic acidosis during tenofovir disoproxil fumarate and cobicistat combination for HIV patient
Atsushi Isoda,
Masahiro Mihara,
Morio Matsumoto
et al.
Abstract:Lactic acidosis is a rare but serious side effect in individuals receiving nucleoside reverse transcriptase inhibitors. An underweight woman with HIV was admitted to our hospital because of nausea and diffuse myalgia. Her antiretroviral regimen had been changed to tenofovir disoproxil fumarate (TDF)/emtricitabine and darunavir/cobicistat 3 months prior, after which her renal function had gradually declined. After admission, she was diagnosed with lactic acidosis, and a liver biopsy suggested mitochondrial dama… Show more
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