Severe Iron Deficiency Anemia in 42 Pediatric Patients

Sandoval, Claudio; Berger, Emily; Özkaynak, M. Fevzi; Tugal, Oya; Jayabose, Somasundaram

doi:10.1080/088800102753541305

Cited by 20 publications

(17 citation statements)

References 11 publications

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“…: red meats) and the high intake of cows milk were associated with ID. 25,26 Although there are no nutritional surveys in this study, we may infer that the diet of the analyzed population is not as required, especially because of the high prevalence of VAD observed. 3 With regard to VAD, the most probable hypothesis to explain such prevalence in the analyzed population is that children of this age have a low intake of vitamin-A-rich foods, as observed in other populations with VAD.…”

Section: Discussionmentioning

confidence: 99%

Prevalência da carência de ferro e sua associação com a deficiência de vitamina A em pré-escolares

Ferraz

Daneluzzi

Vannucchi

et al. 2005

J. Pediatr. (Rio J.)

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Objectives: To identify the prevalence of iron deficiency in the population studied, as well as verifying if such deprivation is associated with vitamin A deficiency. Methods:One hundred seventy-nine children, > 24 months and < 72 months of age, with no diarrhea and/or fever at collection were studied. Vitamin A deficiency identification was carried out through serum 30-day doseresponse test. Samples of peripheral blood from fasting children was obtained for hemoglobin counts, serum iron, and unsaturated iron binding capacity assays. Information about the presence of diarrhea and/or fever during the 15 days preceding the study was also obtained.Results: 35.8% (64/179) of the children presented iron deficiency and 75.4% (135/179), vitamin A deficiency. 29.1% (52/179) of the children presented both iron and vitamin A deficiencies. Iron deficiency was not associated with vitamin A deficiency. A separate analysis for each hematimetric index also demonstrated no significant difference between children with or without vitamin A deficiency. Children aged 24 to 36 months presented significantly higher prevalence rates of iron deficiency (p = 0.0005) as did children with diarrhea and/or fever during the 15 days preceding the study (p = 0.003).Conclusions: Although iron deficiency was not associated with vitamin A deficiency, high rates of both deficiencies were exhibited in a healthy population with low malnutrition indices. Such situations are known as hidden hunger. Younger children presented a higher risk of iron deficiency as did children with diarrhea and/or fever during the 15 days preceding the study.

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Section: Discussionmentioning

confidence: 99%

Prevalência da carência de ferro e sua associação com a deficiência de vitamina A em pré-escolares

Ferraz

Daneluzzi

Vannucchi

et al. 2005

J. Pediatr. (Rio J.)

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“…Most patients with iron deficiency will have normal or elevated platelet counts, some higher than 1,000 × 10 9 /L at diagnosis [3]; thrombocytopenia in association with iron deficiency is relatively rare. In a case series of 42 children with severe iron deficiency anemia, only 1 patient (2.4%) had a platelet count less than 100 × 10 9 /L [4]. Similarly, only 2 of 86 (2.3%) adult women with iron deficiency anemia had thrombocytopenia [5].…”

Section: Introductionmentioning

confidence: 99%

Severe Thrombocytopenia With Iron Deficiency Anemia

Morris¹,

Spraker²,

Howard³

et al. 2010

Pediatric Hematology and Oncology

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Objective Although severe thrombocytopenia has been reported among children with iron deficiency anemia, the presence of both anemia and thrombocytopenia can suggest serious or malignant bone marrow dysfunction, requiring further work-up. This paper reviews the management and outcomes of patients with the diagnosis of iron deficiency anemia presenting with severe thrombocytopenia. Methods We present four pediatric patients with iron deficiency anemia and severe thrombocytopenia at initial presentation. Charts were reviewed after approval by the institutional review boards at both St. Jude Children’s Research Hospital and LeBonheur Children’s Medical Center in Memphis, Tennessee. Results and Conclusions All four patient’s hemoglobin concentrations and platelet counts normalized within one to three weeks of initiating iron supplementation, suggesting that in such patients iron supplementation can obviate the need for invasive diagnostic procedures. In addition, these patients all had a platelet “overshoot” phenomenon during iron therapy prior to normalization of platelet counts, the mechanism of which is still unknown. The literature exploring the mechanism behind our clinical findings is reviewed.

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“…Despite some improvement during the past several decades, children in the second year of life are the most vulnerable to severe iron deficiency anemia. 29 A recent National Health and Nutrition Examination Study estimated that 2% of children in their second year of life had iron deficiency anemia, whereas 7% were iron deficient. 30 High-risk populations, such as the poor and minorities, have shown much greater rates of iron deficiency and iron deficiency anemia in this age group.…”

Section: Introductionmentioning

confidence: 99%

Excessive Cow's Milk Consumption and Iron Deficiency in Toddlers

Bondi

Lieuw

2009

ICAN: Infant, Child, & Adolescent Nutrition

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Elimination of iron deficiency and iron deficiency anemia in children is a crucial public health concern because these conditions have been linked to cognitive and behavioral deficits. In the infant age group, great strides have been made to reduce iron deficiency and iron deficiency anemia significantly. However, similar progress has not yet been made with toddlers. Cow's milk consumption has long been associated with iron deficiency and iron deficiency anemia in children. Because cow's milk is a staple in the diet of most toddlers, they are at particular risk for these conditions. Two unusual presentations of anemia in toddlers caused by excessive cow's milk consumption are described: one in a child with congestive heart failure, the other in a child with profound eosinophilia. The role of cow's milk in iron deficiency and iron deficiency anemia is also examined.

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Severe Iron Deficiency Anemia in 42 Pediatric Patients

Cited by 20 publications

References 11 publications

Prevalência da carência de ferro e sua associação com a deficiência de vitamina A em pré-escolares

Prevalência da carência de ferro e sua associação com a deficiência de vitamina A em pré-escolares

Severe Thrombocytopenia With Iron Deficiency Anemia

Excessive Cow's Milk Consumption and Iron Deficiency in Toddlers

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