Severe intoxication by psychotropic drugs; syndrome serotoninergic

Abstract

Among the intoxications by psychotropic drugs we have the serotoninergic syndrome (SS) which is an adverse pharmacological reaction of lethal character being of therapeutic use, intentional overdose, interactions of involuntary form because of drugs with activity on the serotonin receptors, this leads as a consequence a clinical picture of mild to fatal consequences including alteration of the mental state, overactivity of the autonomic nervous system, neuromuscular hyperreactivity, its diagnosis is directed in the essential clinical history, taking drugs and knowing the possible pharmacological interactions, in addition to the physical examination, support of laboratory tests and images, since this will affect its prognosis, its treatment is directed to life support measures, accompanied by pharmacological antagonists. Next, we present a case of a patient with a history of major depression, anxiety polymedicated with flouxetine, quetiapine, alprazolam, carbamazepine, causing toxicity induced by drugs that stimulated the 5-hydroxytryptimine receptors which produce affectation of the mental state, increase of the autonomic activity, neuromuscular alteration.