Severe intestinal obstruction due to Strongyloides stercoralis in a pregnant woman

Malézieux-Picard, Astrid; Saint–Paul, Marie–Christine; Dellamonica, Jean; Courjon, Johan; Tieulié, N.; Marty, P.; Fuzibet, J. G.; Collomp, Rémy; Marinho, J.; Queyrel, V.

doi:10.1016/j.medmal.2017.05.007

Cited by 11 publications

(17 citation statements)

References 10 publications

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“…Four case reports were found as part of the literature search that fulfilled our inclusion criteria ( Table 7 ) [ 49 , 50 , 51 , 52 ]. All four cases describe women who presented at varying stages of gestation with predominantly gastrointestinal or respiratory symptoms.…”

Section: Resultsmentioning

confidence: 99%

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The Health Effects of Strongyloidiasis on Pregnant Women and Children: A Systematic Literature Review

Paltridge¹,

Traves²

2018

TropicalMed

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Strongyloidiasis is a helminth infection that remains under-researched despite its ability to cause significant illness. Women and children may be at particular risk of health consequences from this parasite. This systematic literature review aims to examine research on the long-term health effects that strongyloidiasis has in pregnant women and children. We conducted a structured search using multiple databases to collect all primary studies discussing health effects of strongyloidiasis in the aforementioned groups. The review included 20 results: 16 primary studies and four case reports. The methodological quality of studies was substandard, and there was substantial heterogeneity to the statistical analysis and outcomes assessed in the literature. Statistically significant associations were found between strongyloidiasis and low birth weight, as well as wasting. No links were found between strongyloidiasis and anaemia. Due to testing methods used in the studies, the prevalence of Strongyloides stercoralis in these studies was probably under-estimated. Current research is suggestive that strongyloidiasis has long-term adverse health effects on the offspring of infected mothers and in chronically-infected children. Data analysis was hindered by both methodological and statistical flaws, and as such, reliable conclusions regarding the health impacts could not be formed.

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Section: Resultsmentioning

confidence: 99%

“…Of the three women who survived, all underwent spontaneous vaginal births to healthy babies, with no complications. They made a full recovery from the infection, although one mother re-presented a year later, again pregnant and suffering from gastrointestinal symptoms [ 50 ]. She was found to have been re-infected with S. stercoralis .…”

Section: Resultsmentioning

confidence: 99%

The Health Effects of Strongyloidiasis on Pregnant Women and Children: A Systematic Literature Review

Paltridge¹,

Traves²

2018

TropicalMed

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“…Few case reports have been found in the medical literature on Strongyloides hyperinfection in pregnancy. 10,[43][44][45] In two of the cases reported, both the mother and the fetus died. In the other two, both recovered successfully.…”

Section: Risk Of Disseminated Diseasementioning

confidence: 99%

A Review on Strongyloidiasis in Pregnant Women

Wikman-Jorgensen

Requena‐Méndez

Llenas-García

2021

RRTM

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Strongyloidiasis is a parasitic infection distributed worldwide, with an estimated 614 million people infected. Strongyloidiasis usually presents asymptomatically or with aspecific and mild clinical symptoms, mainly cutaneous, respiratory, or gastrointestinal. Disseminated disease and hyperinfection syndrome are the most serious complications, have a high mortality rate, usually occur in immunosuppressed patients, and are particularly associated with the use of corticosteroids. Strongyloidiasis is the most neglected of the neglected diseases, and its occurrence in pregnancy has been neglected and understudied. In this review, we focus on the effects of strongyloidiasis during pregnancy and highlight the knowledge shortage and the need for more research on the subject. There are few studies addressing strongyloidiasis prevalence during pregnancy and hyperinfection incidence during pregnancy is practically unknown, with only isolated case reports published. Although data are scarce, the infection has been associated with developmental disabilities and anemia during pregnancy, while hyperinfection may cause both maternal and neonatal death. Data on the best screening and diagnostic strategies during pregnancy are lacking. There is insufficient evidence on ivermectin safety in pregnancy, complicating treatment recommendations.

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“…Obstructive GI disease has been characterized in a number of other co-infected patients [16,17]. In one case, intestinal obstruction induced by S. stercoralis was observed in a pregnant woman following corticosteroid treatment, and it was subsequently determined that she was an HTLV-1 carrier [18]. Another report described a household in rural Brazil, in which the entire family was HTLV-1 positive, and the 13-year-old son exhibited eosinophilia and very large numbers of S. stercoralis worms, larvae, and eggs [19].…”

Section: Case Reports Of Htlv-1 and S Stercoralis Co-infectionmentioning

confidence: 99%

Human T-cell Leukemia Virus Type 1 and Strongyloides stercoralis: Partners in Pathogenesis

et al. 2020

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Infection with human T-cell leukemia/lymphoma virus type 1 (HTLV-1) has been associated with various clinical syndromes including co-infection with Strongyloides stercoralis, which is an intestinal parasitic nematode and the leading cause of strongyloidiasis in humans. Interestingly, HTLV-1 endemic areas coincide with regions citing high prevalence of S. stercoralis infection, making these communities optimal for elucidating the pathogenesis of co-infection and its clinical significance. HTLV-1 co-infection with S. stercoralis has been observed for decades in a number of published patient cases and case series; however, the implications of this co-infection remain elusive. Thus far, data suggest that S. stercoralis increases proviral load in patients co-infected with HTLV-1 compared to HTLV-1 infection alone. Furthermore, co-infection with HTLV-1 has been associated with shifting the immune response from Th2 to Th1, affecting the ability of the immune system to address the helminth infection. Thus, despite this well-known association, further research is required to fully elucidate the impact of each pathogen on disease manifestations in co-infected patients. This review provides an analytical view of studies that have evaluated the variation within HTLV-1 patients in susceptibility to S. stercoralis infection, as well as the effects of strongyloidiasis on HTLV-1 pathogenesis. Further, it provides a compilation of available clinical reports on the epidemiology and pathology of HTLV-1 with parasitic co-infection as well as data from mechanistic studies suggesting possible immunopathogenic mechanisms. Furthermore, specific areas of potential future research have been highlighted to facilitate advancing understanding of the complex interactions between these two pathogens.

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Severe intestinal obstruction due to Strongyloides stercoralis in a pregnant woman

Cited by 11 publications

References 10 publications

The Health Effects of Strongyloidiasis on Pregnant Women and Children: A Systematic Literature Review

The Health Effects of Strongyloidiasis on Pregnant Women and Children: A Systematic Literature Review

A Review on Strongyloidiasis in Pregnant Women

Human T-cell Leukemia Virus Type 1 and Strongyloides stercoralis: Partners in Pathogenesis

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