Severe insulin allergy successfully treated with continuous subcutaneous insulin infusion

Fujikawa, Tatsuya; Imbe, Hisashi; Date, Masamichi; Go, Yoshie; Kitaoka, Haruko

doi:10.1016/j.diabres.2012.04.027

Cited by 20 publications

(23 citation statements)

References 16 publications

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“…Anaphylaxis was suspected when the same skin reaction occurred even after switching the soft cannula site. There are previous cases reported that insulin allergy was an important cause that resulted in induration, swelling and redness at injection site 7,8. But, this patient had had no allergy symptoms since starting insulin therapy seven months ago and still had no swelling or redness at injection site when switched to multiple daily insulin injections in our hospital.…”

Section: Discussionmentioning

confidence: 65%

Allergy to soft cannula of insulin pump in diabetic patient

Chen

Huang

2017

Pak J Med Sci

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Insulin pump is a relatively good choice for diabetic patients who require multiple daily injections with wide fluctuations of blood glucose. Patients using insulin pump therapy and still having uncontrolled blood glucose levels for various factors: insulin pump not working properly, insulin instability, insulin autoantibody, insulin allergy, etc. We described a 46-year-old woman with type 2 diabetes and progressive hyperglycemia after switching multiple daily insulin injections to insulin pump, due to allergy to soft cannula of insulin pump.

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Section: Discussionmentioning

confidence: 65%

Allergy to soft cannula of insulin pump in diabetic patient

Chen

Huang

2017

Pak J Med Sci

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“…Long‐acting insulin glargine and CSII with short‐acting insulin analogues have both reportedly been used to manage patients with insulin allergy ; however, our patient was allergic to glargine and other analogues, such that none of these treatments could be used. After starting treatment with IDeg, the allergic reactions completely disappeared.…”

Section: Discussionmentioning

confidence: 87%

A case of insulin allergy successfully managed using multihexamer‐forming insulin degludec combined with liraglutide

et al. 2016

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Our patient was allergic to all insulin formulations except insulin degludec. Her allergic reactions completely disappeared after switching to insulin degludec. The crystallized structure of this insulin might mask its skin allergen antigenicity. Furthermore, her postprandial hyperglycaemia was successfully controlled with liraglutide. We propose multihexamer-forming ultra-long-acting insulin plus glucagon-like peptide-1 analogues as a therapeutic option for patients with insulin allergy.

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“…This is not the first description of the use of CSII to treat localised insulin allergy in patients with either type 1 or type 2 diabetes, [2][3][4][5][6] and our patient's symptoms were significantly and sufficiently improved rather than cured. However, we are not aware of other examples where i-Port Advance™, a device that has been developed to make it possible for people with needle phobia to be able to inject insulin themselves, has been used for this indication.…”

Section: Discussionmentioning

confidence: 99%