Severe Infections with Human Adenovirus 7d in 2 Adults in Family, Illinois, USA, 2014

Kajon, Adriana E.; Ison, Michael G.

doi:10.3201/eid2204.151403

Cited by 35 publications

(34 citation statements)

References 15 publications

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“…It was also the prevalent genome type in Japan during 1987 to 199246 and in Korea during two outbreaks in 1995–1996 and 2001–200247, with a high fatality rate (18%) in children48. Recently, it emerged to cause adult severe CAP in the USA during 2013–20142732. In our study, HAdV-7d caused more severe clinical manifestations and adverse consequences than other types, particularly HAdV-3 and HAdV-2 (61 and 12 cases, respectively), with longer duration of fever, higher morbidity of tachypnea/dyspnea, pleural effusion, diarrhea, hepatosplenomegaly, and consciousness alteration, as well as with higher rates of pneumonia, mechanical ventilation and death.…”

Section: Discussionmentioning

confidence: 99%

“…HAdV-7 is one of the most important respiratory HAdVs and has been circulating both in military and civilian populations. It accounts for nearly 20% of all HAdVs reported to the World Health Organization24 and is associated with severe respiratory disease13252627.…”

mentioning

confidence: 99%

“…The three recent isolates circulating in Southern China (DG01; 2011), Southwestern China (CQ1198; 2010), and Northwestern China (0901HZ/ShX; 2009) were identified as a re-emergent genome type 7d (HAdV-7d) after approximately 20-year absence in China1. In the United States, the recent emergence of HAdV-7d during 2013–2014 caused many hospitalizations and fatal CAP in adult civilians2732. These emergent or re-emergent HAdV-7d variants may have powerful potential to cause more outbreaks, not only in Asia with its dense population centers, but also in Americas.…”

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confidence: 99%

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Fatal Community-acquired Pneumonia in Children Caused by Re-emergent Human Adenovirus 7d Associated with Higher Severity of Illness and Fatality Rate

Zeng

Zhang

et al. 2016

Sci Rep

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Human adenoviruses (HAdVs) are highly contagious pathogens causing acute respiratory disease (ARD), such as community-acquired pneumonia. HAdV-7d, a re-emergent genomic variant, has been recently reported in Asia and the United States after a several-decade absence. However, whether HAdV-7d is associated with higher severity than other types is currently unclear. In this study, the clinical and epidemiological investigation showed that fever, cough, and sore throat were the three most common respiratory symptoms of HAdV infections. HAdV-7 caused longer duration of fever, higher morbidity of tachypnea/dyspnea, pleural effusion, diarrhea, hepatosplenomegaly, consciousness alteration, as well as higher rates of pneumonia, mechanical ventilation and higher fatality rate (28.6%) than other types, particularly HAdV-3 and HAdV-2. The genomes of seven HAdV-7d isolates from mild, severe, and fatal cases were sequenced and highly similar with each other. Surprisingly, two isolates (2011, 2012) had 100% identical genomes with an earlier strain from a fatal ARD outbreak in China (2009), which elucidates the virus origin and confirms the unexpected HAdV genomic conservation and stability. Phylogenetic analysis indicated that L1 52/55-kDa DNA packaging protein may be associated with the higher severity of illness and fatality rate of HAdV-7. Clinicians need to be aware of HAdVs in children with ARD.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Fatal Community-acquired Pneumonia in Children Caused by Re-emergent Human Adenovirus 7d Associated with Higher Severity of Illness and Fatality Rate

Zeng

Zhang

et al. 2016

Sci Rep

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“…All these factors contribute to the outbreak potential of HAdVs. The potential for outbreaks of respiratory disease has led to the development of a vaccine to be used among US military recruits [16,17].…”

Section: Introductionmentioning

confidence: 99%

Molecular epidemiology of human adenovirus infections in Denmark, 2011–2016

Barnadas

Schmidt

Fischer

et al. 2018

Journal of Clinical Virology

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“…Recently there have been small, localised outbreaks of pulmonary adenovirus infections described in Oregon and Illinois further highlighting the need to consider the pathogen in clinical practice 13 14…”

Section: Discussionmentioning

confidence: 99%

Disseminated adenovirus infection causing severe ARDS

2017

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A previously healthy young man with a rare genetic condition presented with severe acute respiratory distress syndrome secondary to pneumonia with septic shock. He did not improve with conventional therapy for his known causal organism thus prompting further workup. He was found to be profoundly immunosuppressed raising our suspicion for atypical organisms. A bronchoalveolar lavage sample was positive via PCR for adenovirus which we suspect exacerbated a pre-existing bacterial pneumonia and led to a severe and non-responsive respiratory failure. His serum adenovirus load was markedly elevated. Treatment was started once the diagnosis of disseminated adenovirus infection was made; however, at that time patient was suffering from refractory hypoxaemia, respiratory acidosis, right heart failure and septic shock. Despite maximal supportive measures our patient ultimately expired over the course of 6 days.

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Severe Infections with Human Adenovirus 7d in 2 Adults in Family, Illinois, USA, 2014

Cited by 35 publications

References 15 publications

Fatal Community-acquired Pneumonia in Children Caused by Re-emergent Human Adenovirus 7d Associated with Higher Severity of Illness and Fatality Rate

Fatal Community-acquired Pneumonia in Children Caused by Re-emergent Human Adenovirus 7d Associated with Higher Severity of Illness and Fatality Rate

Molecular epidemiology of human adenovirus infections in Denmark, 2011–2016

Disseminated adenovirus infection causing severe ARDS

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