Severe<i>Plasmodium vivax</i>Malaria, Brazilian Amazon

Alexandre, Márcia A. A.; Ferreira, Cynthia O.; Siqueira, André Machado; Magalhaes, Belisa L.; Mourão, Maria Paula Gomes; Lacerda, Marcus Vinícius Guimarães; Alecrim, Maria das Graças Costa

doi:10.3201/eid1610.100685

Cited by 192 publications

(174 citation statements)

References 13 publications

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“…Data on parasitemia at day 28 after treatment were not available for all the patients and thus did not allow an evaluation of the possible development of in vivo chloroquine resistance, in line with other studies in the Brazilian Amazon 20 . Prospective studies need to be developed in the area for a better understanding of the issue.…”

Section: Conflict Of Interestmentioning

confidence: 99%

Plasmodium vivax malaria: related factors to severity in the State of Maranhão, Brazil

Raposo

Santos

Santos³

et al. 2013

Rev. Soc. Bras. Med. Trop.

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Introduction: Malaria caused by Plasmodium vivax species has shown signs of severity, recorded with increasing frequency in the medical literature. This study aimed to characterize the signs of severe malaria by Plasmodium vivax in the State of Maranhão, Brazil. Methods: A descriptive cohort study of patients assisted in the field and a historical and concurrent study of a series of cases among hospitalized patients were undertaken to identify the clinical and laboratory signs of severity. Results: A total of 153 patients were included in the study, 13 of whom were hospitalized. Males made up the majority, numbering 103 (67.3%). The age of the patients ranged from 10 to 70 years, 92.2% were natives of the State of Maranhão, and 65% of the patients had had malaria before. The average time elapsed between symptom onset and diagnosis among outpatients was three days, while among hospitalized patients this average reached 15.5 days, a statistically significant difference (p=0.001). The parasitemia ranged from 500 to 10,000 parasites/µl in 92.8% of cases. The clinical and laboratory manifestations of severity were vomiting and diarrhea, jaundice, drowsiness, mental confusion, seizures, loss of consciousness, agitation, bleeding, pale skin, coughing and dyspnea, thrombocytopenia, anemia, elevation of nitrogenous compounds, and elevated transaminases and bilirubin. Conclusions: The monitoring of malaria patients with Plasmodium vivax showed the possibility of aggravation, the intensity of which varied in different circumstances, especially the interval time between falling ill and diagnostic confirmation.

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Section: Conflict Of Interestmentioning

confidence: 99%

Plasmodium vivax malaria: related factors to severity in the State of Maranhão, Brazil

Raposo

Santos

Santos³

et al. 2013

Rev. Soc. Bras. Med. Trop.

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“…Severe and fatal vivax malaria has been reported from Indonesia, 52,53 Papua New Guinea, 54 India, 55 and Brazil. 56,57 The main manifestations are anemia and respiratory distress, 53,[56][57][58][59][60][61][62] although series of patients with coma, shock, and renal and hepatic dysfunction associated with vivax malaria have also been described. [55][56][57]61,62 Plasmodium vivax is very sensitive to artemisinin and its derivatives.…”

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confidence: 99%

“…56,57 The main manifestations are anemia and respiratory distress, 53,[56][57][58][59][60][61][62] although series of patients with coma, shock, and renal and hepatic dysfunction associated with vivax malaria have also been described. [55][56][57]61,62 Plasmodium vivax is very sensitive to artemisinin and its derivatives. In the absence of comparative drug trials, physicians have tended to adopt a similar treatment approach for severe vivax malaria as for severe falciparum malaria, 1 namely administration of parenteral artesunate, if unavailable, artemether, and if that is also not available then quinine, along with broad-spectrum antibiotic cover and supportive care.…”

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Diagnosis and Treatment of Plasmodium vivax Malaria

Baird

Maguire

Price

2012

Advances in Parasitology

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“…De todos modos, es importante destacar el peso que viene ganando P. vivax como responsable de presentaciones clínicas graves en diferentes partes del mundo, así como en la región de Urabá (15)(16)(17)(18)(19)(20)(21)(22)(23)(24).…”

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Clinical and laboratory profile of Plasmodium vivax malaria patients hospitalized in Apartadó,

et al. 2012

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Introducción. La malaria representa un problema de salud pública en la región de Urabá, donde se registran tasas superiores a las del departamento de Antioquia; la carga de malaria por Plasmodium vivax es de 78,7 % y poco se ha explorado su perfil en la región.Objetivos. Con el presente estudio se pretende conocer las características clínicas y de laboratorio de los pacientes hospitalizados por malaria por P. vivax en Apartadó.Materiales y métodos. Se revisaron las historias clínicas de pacientes con malaria por P. vivax que requirieron manejo hospitalario en el Hospital “Antonio Roldán Betancur”, Empresa Social del Estado, durante los años 2004-2007.Resultados. Se hospitalizaron 359 pacientes con malaria por P. vivax, de los cuales, el 23,1 % (83/359 casos) se complicó por anemia grave (51,8 %, 43/83), por trombocitopenia grave (15,6 %, 13/83) y por hiperbilirrubinemia (7,2 %, 6/83); algunos pacientes satisfacían varios criterios simultáneamente, incluyendo un caso de síndrome de dificultad respiratoria aguda. Los datos de laboratorio más significativos mostraron disminución de los niveles de hemoglobina, hematocrito y plaquetas, con aumento en los niveles de transaminasas y bilirrubinas. Sólo el 4,82 % (4/83) de los pacientes con malaria complicada, recibió tratamiento con quinina intravenosa, ninguno falleció.Conclusiones. Se destaca en este trabajo la frecuencia importante de malaria complicada por P. vivax, particularmente en los menores de cinco años, en la región de Urabá, y la necesidad de fortalecer el conocimiento de la guía para la atención clínica integral del paciente con malaria, entre el personal de salud, para hacer un diagnóstico clínico correcto y ofrecer el tratamiento apropiado.

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SeverePlasmodium vivaxMalaria, Brazilian Amazon

Cited by 192 publications

References 13 publications

Plasmodium vivax malaria: related factors to severity in the State of Maranhão, Brazil

Plasmodium vivax malaria: related factors to severity in the State of Maranhão, Brazil

Diagnosis and Treatment of Plasmodium vivax Malaria

Clinical and laboratory profile of Plasmodium vivax malaria patients hospitalized in Apartadó,

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