Severe Hypotension Is Not Essential for Isoflurane Neuroprotection against Forebrain Ischemia in Mice

Homi, H. Mayumi; Mixco, Javier; Sheng, Tao; Grocott, Hilaty P.; Pearlstein, Robert D.; Warner, David S.

doi:10.1097/00000542-200311000-00022

Cited by 38 publications

(12 citation statements)

References 31 publications

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“…The neurological assessments were performed at 24, 48 or 72 h post-reperfusion by an observer in a blinded manner. The TMS has been shown previously to be an accurate method for evaluating global cerebral ischemic injury in mice (27).…”

Section: Animalsmentioning

confidence: 99%

Neuroprotective effects of lycopene pretreatment on transient global cerebral ischemia-reperfusion in rats: The role of the Nrf2/HO-1 signaling pathway

Lei

Zhang

et al. 2015

Molecular Medicine Reports

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Abstract. The present study aimed to investigate the neuroprotective effect of lycopene in a mouse model of bilateral common carotid artery occlusion (BCCAO) and the role of the Nrf2/HO-1 signaling pathway. A total of 60 male C57BL/6 mice, aged 12 weeks and weighing 20-24 g, were used in the present study. The mice were randomly assigned to three groups: Control, BCCAO and BCCAO + lycopene. The neurological score was assessed 24, 48 or 72 h following BCCAO. Hematoxylin and eosin staining, and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) were performed to detect neuronal death and survival. The production of glutathione (GSH) and reactive oxygen species were detected to investigate the oxidative stress. The expression levels of nuclear factor erythroid 2-related factor (Nrf2) and Heme oxygenase-1 (HO-1) were determined by western blotting. Lycopene significantly improved the neurological score in the BCCAO mice. It attenuated neuronal apoptosis, as indicated by TUNEL staining, and attenuated the oxidative stress induced by global ischemia. Lycopene increased the expression levels of Nrf2 and HO-1, indicating that the Nrf2/HO-1 signaling pathway may be involved in the neuroprotective effect of lycopene. The present study revealed that lycopene protects the brain from global ischemic injury, which is associated with its antiapoptotic effect and the activation of the Nrf2/HO-1 signaling pathway.

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Section: Animalsmentioning

confidence: 99%

Neuroprotective effects of lycopene pretreatment on transient global cerebral ischemia-reperfusion in rats: The role of the Nrf2/HO-1 signaling pathway

Lei

Zhang

et al. 2015

Molecular Medicine Reports

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“…The neurologic tests were performed at 24-, 48-, and 72-h post-reperfusion by an observer who was blind to the grouping. The total motor score (TMS) has been shown to be an accurate test for evaluating global cerebral ischemia injury in mice (11,26).…”

Section: Neurological Testsmentioning

confidence: 99%

The neuroprotective effects of resveratrol preconditioning in transient global cerebral ischemia-reperfusion in mice

Liu

Sun²,

Li³

2015

Turkish Neurosurgery

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“…Isofl urane proved to be a superior neuroprotective agent to a combined regimen of nitrous oxide and fentanyl in mice assessed three days after bilateral carotid artery occlusion in cognitive and histological function tests 94 . Additionally, in a model of traumatic brain injury in rats, isofl urane provided better neuroprotection than fentanyl when both were administered in combination with nitrous oxide 28 .…”

Section: Volatile Anestheticsmentioning

confidence: 93%

Anestésicos, precondicionamento e proteção cerebral

Nunes¹,

Neto²,

Alencar³

et al. 2013

Rev. Bras. Anestesiol.

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Background and objectives: Several studies demonstrate that cerebral preconditioning is a protective mechanism against a stressful situation. Preconditioning determinants are described, as well as the neuroprotection provided by anesthetic and non-anesthetics agents. Content: Review based on the main articles addressing the pathophysiology of ischemia-reperfusion and neuronal injury and pharmacological and non-pharmacological factors (infl ammation, glycemia, and temperature) related to the change in response to ischemia-reperfusion, in addition to neuroprotection induced by anesthetic use. Conclusions: The brain has the ability to protect itself against ischemia when stimulated. The elucidation of this mechanism enables the application of preconditioning inducing substances (some anesthetics), other drugs, and non-pharmacological measures, such as hypothermia, aimed at inducing tolerance to ischemic lesions.

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Severe Hypotension Is Not Essential for Isoflurane Neuroprotection against Forebrain Ischemia in Mice

Cited by 38 publications

References 31 publications

Neuroprotective effects of lycopene pretreatment on transient global cerebral ischemia-reperfusion in rats: The role of the Nrf2/HO-1 signaling pathway

Neuroprotective effects of lycopene pretreatment on transient global cerebral ischemia-reperfusion in rats: The role of the Nrf2/HO-1 signaling pathway

The neuroprotective effects of resveratrol preconditioning in transient global cerebral ischemia-reperfusion in mice

Anestésicos, precondicionamento e proteção cerebral

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