Severe hypoglycaemia during treatment with sulphonylureas in patients with type 2 diabetes in the Capital Region of Denmark

Pilemann-Lyberg, Sascha; Thorsteinsson, Birger; Snorgaard, Ole; Zander, Mette; Vestergaard, Henrik; Röder, Michael

doi:10.1016/j.diabres.2015.09.006

Cited by 10 publications

(7 citation statements)

References 27 publications

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“…The use of oral diabetic agents has been found to elevate the risk of hypoglycemia as established by many studies [19,[27][28]. This was not observed in the current study, as we observed no differences between the study groups regarding the use of oral hypoglycemic medications on developing hypoglycemia.…”

Section: Discussioncontrasting

confidence: 57%

Hypoglycemic Risk Factors Among Hospitalized Patients with Type 2 Diabetes Mellitus at King Abdulaziz Medical City, Jeddah

Alghamdi

Alghubayshi

Alshamrani

et al. 2020

Cureus

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Background Hypoglycemia is a pathological condition in which the serum glucose level measures less than 3.0 mmol/L. It is a well-known complication in patients with diabetes mellitus. Age, body weight, gender, insulin usage, nutritional therapy, body mass index (BMI), the presence of diabetes complications, intensive care unit admission, and infection were reported as possible risk factors that may increase the risk of hypoglycemia. Therefore, this study aimed to analyze predisposing factors for hypoglycemia among hospitalized patients with type 2 diabetes in King Abdulaziz Medical City. Method This is a retrospective, case-control study design. The study included 326 hospitalized patients with type 2 diabetes; 152 experienced hypoglycemia (blood glucose <3.9) at least once during hospitalization and have been compared to 174 in the non-hypoglycemic group (blood glucose ≥3.9). Data were extracted from their electronic medical records (EMRs). Results This study reported that patients with lower BMI (28.80 ± 7 versus 31.20 ± 12.93) experienced hypoglycemia (P-value 0.044). Those hospitalized with infections or had acquired infections or required intensive care unit (ICU) admission during hospitalization had a higher risk to develop hypoglycemia (P-value 0.005, 0.003, and <0.001, respectively). Moreover, the use of multiple doses of insulin therapy or basal-plus insulin therapy was associated with a higher risk of hypoglycemia (P-value 0.012 and 0.028, respectively). Those on supplemental insulin were less likely to develop hypoglycemia (P-value <0.001). Patients on oral feeding had a lower chance of having a hypoglycemic attack (P-value 0.002) while those on tube feeding had double the odds (OR=2.37). Conclusions Infection, intensive care unit admission, lower body mass index, insulin regimen and nutritional therapy (enteral feeding and nothing-per-mouth (NPO)) were correlated with an elevated risk of having hypoglycemia in hospitalized patients with type 2 diabetes mellitus.

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Section: Discussioncontrasting

confidence: 57%

Hypoglycemic Risk Factors Among Hospitalized Patients with Type 2 Diabetes Mellitus at King Abdulaziz Medical City, Jeddah

Alghamdi

Alghubayshi

Alshamrani

et al. 2020

Cureus

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“…The investigators suggested that those medicines may have to be used with caution in elderly patients, in patients with renal, hepatic or cardiovascular diseases and in patients with an acute infection, and also in malnourished patients. They also suggested that the control of glucose levels in those patients should be less strict to avoid severe complications of hypoglycaemia [29]. On the other hand, no episodes of severe hypoglycaemia in patients receiving SU were found in the present survey, which may be due to the small size of the surveyed group (n = 24).…”

Section: Discussioncontrasting

confidence: 48%

Ocena częstości występowania hipoglikemii w zależności od aktywności fizycznej

Zielińska

Bysiak-Korus

Sosna-Kondera

et al. 2018

Clinical Diabetology

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“…According to the ARNO observatory database, glibenclamide, singly or in combination with metformin, is widely used in Italy for the treatment of diabetes, whereas repaglinide is frequently prescribed for older type 2 diabetic patients with CKD [18] . However, given the strong ability of both glibenclamide and repaglinide to increase pancreatic insulin secretion, these two oral drugs may confer a higher risk of drug-induced hypoglycemias, especially in older patients with multiple co-morbidities [19] . Conversely, in our study, a very small number of patients were treated with either glitazones or incretin-based therapies.…”

Section: Discussionmentioning

confidence: 99%

Severe hypoglycemia in patients with known diabetes requiring emergency department care: A report from an Italian multicenter study

Mantovani

Grani

Chioma

et al. 2016

Journal of Clinical & Translational Endocrinology

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Severe hypoglycaemia during treatment with sulphonylureas in patients with type 2 diabetes in the Capital Region of Denmark

Cited by 10 publications

References 27 publications

Hypoglycemic Risk Factors Among Hospitalized Patients with Type 2 Diabetes Mellitus at King Abdulaziz Medical City, Jeddah

Hypoglycemic Risk Factors Among Hospitalized Patients with Type 2 Diabetes Mellitus at King Abdulaziz Medical City, Jeddah

Ocena częstości występowania hipoglikemii w zależności od aktywności fizycznej

Severe hypoglycemia in patients with known diabetes requiring emergency department care: A report from an Italian multicenter study

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