Severe hypoglycaemia during pregnancy in women with type 1 diabetes: Possible role of renin–angiotensin system activity?

Ringholm, Lene; Pedersen‐Bjergaard, Ulrik; Thorsteinsson, Birger; Boomsma, Frans; Damm, Peter; Mathiesen, Elisabeth Reinhardt

doi:10.1016/j.diabres.2009.01.006

Cited by 10 publications

(19 citation statements)

References 33 publications

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“…Prorenin concentration was given as nanograms angiotensin I per millilitre per hour (ng AI ml −1 h −1 ). For all assays, intra-and interassay CVs were below 10% [5,6].…”

Section: Methodsmentioning

confidence: 92%

“…In a prospective observational study we consecutively included 107 Danish-speaking Europid women with type 1 diabetes referred to the Center for Pregnant Women with Diabetes, Rigshospitalet, before 14 completed gestational weeks with a single living fetus, from September 2004 to August 2006 [5].…”

Section: Methodsmentioning

confidence: 99%

“…Blood sampling was performed at medians of 8 (range 5-13), 14 (12-16), 21 (20-23), 27 (25-29) and 33 (31-35) weeks and once within 5 days postpartum [5]. Concentrations of prorenin and angiotensinogen and activity of renin, ACE and SSAO were analysed as previously described [5,6].…”

Section: Methodsmentioning

confidence: 99%

“…Concentrations of prorenin and angiotensinogen and activity of renin, ACE and SSAO were analysed as previously described [5,6]. Prorenin concentration was given as nanograms angiotensin I per millilitre per hour (ng AI ml −1 h −1 ).…”

Section: Methodsmentioning

confidence: 99%

“…Weight, HbA 1c , insulin dose and blood pressure were recorded at each clinical consultation at 1 or 2 week intervals throughout pregnancy [5].…”

Section: Methodsmentioning

confidence: 99%

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A high concentration of prorenin in early pregnancy is associated with development of pre-eclampsia in women with type 1 diabetes

et al. 2011

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Aims/hypothesis The aim of this study was to investigate whether components of the renin-angiotensin system and semicarbazide-sensitive amine oxidase (SSAO) are associated with the development of pre-eclampsia in women with type 1 diabetes. , p=0.06) at 8 weeks compared with women without pre-eclampsia. Levels of renin, angiotensinogen and ACE did not differ in the two groups. Throughout pregnancy, prorenin and SSAO levels were 30% (p=0.004) and 16% (p=0.04) higher, respectively, in women developing pre-eclampsia. Using multivariate logistic regression analysis, prorenin concentration at 8 weeks was associated with pre-eclampsia .0], p=0.007), i.e. an increase of prorenin of 100 ng angiotensin I ml −1 h −1 implies a 4.4 times higher risk of subsequent pre-eclampsia. Conclusions/interpretation In type 1 diabetic women with pre-eclampsia, a higher concentration of prorenin in early pregnancy and higher levels of prorenin and SSAO throughout pregnancy were seen.

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“…Prorenin concentration was given as nanograms angiotensin I per millilitre per hour (ng AI ml −1 h −1 ). For all assays, intra-and interassay CVs were below 10% [5,6].…”

Section: Methodsmentioning

confidence: 92%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

“…Weight, HbA 1c , insulin dose and blood pressure were recorded at each clinical consultation at 1 or 2 week intervals throughout pregnancy [5].…”

Section: Methodsmentioning

confidence: 99%

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A high concentration of prorenin in early pregnancy is associated with development of pre-eclampsia in women with type 1 diabetes

et al. 2011

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Implications for the offspring of circulating factors involved in beta cell adaptation in pregnancy

Nalla

Ringholm

Søstrup

et al. 2014

Acta Obstet Gynecol Scand

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Vitamin D insufficiency, preterm delivery and preeclampsia in women with type 1 diabetes – an observational study

Vestgaard

Secher

Ringholm

et al. 2017

Acta Obstet Gynecol Scand

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Introduction. The aim of this study was to evaluate whether vitamin D insufficiency is associated with preterm delivery and preeclampsia in women with type 1 diabetes. Material and methods. An observational study of 198 pregnant women with type 1 diabetes. 25-Hydroxy-Vitamin D and HbA1c were measured in blood samples in early (median 8 weeks, range 5-14) and late (34 weeks, range 32-36) pregnancy. Kidney involvement (microalbuminuria or nephropathy) at inclusion, smoking status at inclusion, preterm delivery (<37 weeks) and preeclampsia (blood pressure ≥140/ 90 mmHg and proteinuria) were registered. Vitamin D supplementation of 10 lg daily was routinely recommended. Results. Thirty-nine (20%) of the 198 women delivered preterm and 16 (8%) developed preeclampsia. Vitamin D insufficiency (<50 nmol/L) was present in 68 women (34%) in early pregnancy and in 73 women (37%) in late pregnancy. Preterm delivery occurred more frequently in women with vitamin D insufficiency in late pregnancy (27% vs. 15%, crude odds ratio 2.1; 95% confidence interval 1.0-4.3, p = 0.04). After adjustment for preexisting kidney involvement, HbA1c in late pregnancy and smoking the association became nonsignificant (adjusted odds ratio 1.8; 95% confidence interval 0.8-3.7). Preeclampsia developed in 11% of women with vitamin D insufficiency vs. 6% of the remaining women (crude odds ratio 1.8; 95% confidence interval 0.9-4.1, p = 0.25). Conclusion. In women with type 1 diabetes, preterm delivery was twice as frequent in women with vitamin D insufficiency in late pregnancy in crude analysis, but in this small study, low vitamin D was not independently associated with preterm birth or preeclampsia.

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Severe hypoglycaemia during pregnancy in women with type 1 diabetes: Possible role of renin–angiotensin system activity?

Cited by 10 publications

References 33 publications

A high concentration of prorenin in early pregnancy is associated with development of pre-eclampsia in women with type 1 diabetes

A high concentration of prorenin in early pregnancy is associated with development of pre-eclampsia in women with type 1 diabetes

Implications for the offspring of circulating factors involved in beta cell adaptation in pregnancy

Vitamin D insufficiency, preterm delivery and preeclampsia in women with type 1 diabetes – an observational study

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