Severe hypocalcemia induced by Denosumab in a patient with Osteroporosis after malabsorptive bariatric surgery

A 59-year-old Female Post Bariatric Surgery with Severe Vitamin D Deficiency and Severe Hypocalcemia Induced by Denosumab Injection for Osteoporosis

“…with mild vitamin D deficiency, yet vitamin D levels remained unchanged after administration of the RANKL inhibitor. The patient improved with eight weeks of IV calcium followed by oral calcium, phosphorus and vitamin D supplementation [9].…”

“…Few other cases highlighting vitamin D levels in denosumabtreated individuals have been reported in literature [8,9]. One patient with osteoporosis and intestinal malabsorption secondary to Crohn's disease who presented with denosumab-induced severe hypocalcemia experienced symptom resolution after a three-day hospitalization.…”