Severe Hypermagnesemia

Nanduri, Ananya; Saleem, Shiraz; Khalaf, Mahmoud

doi:10.1016/j.chest.2020.08.946

Cited by 2 publications

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“…Furthermore, it was also found in this study that excessive Mg supplementation significantly inhibited the growth performance of fish. The speculation is that high Mg intakes might impair gastrointestinal function [44]. In addition, whole-body crude protein content was significantly elevated when dietary MgO NPs levels increased from 0 to 120 mg/kg.…”

Section: Discussionmentioning

confidence: 99%

The Benefits of Nanosized Magnesium Oxide in Fish Megalobrama amblycephala: Evidence in Growth Performance, Redox Defense, Glucose Metabolism, and Magnesium Homeostasis

et al. 2023

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This study evaluated the effects of dietary magnesium oxide nanoparticles (MgO NPs) on the growth, redox defense, glucose metabolism, and magnesium homeostasis in blunt snout bream. Fish (12.42 ± 0.33 g) were fed seven diets containing graded levels of MgO NPs (0, 60, 120, 240, 480, 960, and 1920 mg/kg) for 12 weeks. Whole-body Mg retention decreased significantly as the dietary Mg increased. As dietary MgO NPs levels reached 120 mg/kg, the growth performance and feed utilization remarkably improved. When added at 240 mg/kg, oxidative stress was significantly reduced evidenced by the increased Mn-sod transcription and the decreased CAT and GSH-Px activities and the MDA content. Meanwhile, it enhanced glucose transport, glycolysis, and glycogen synthesis, while inhibiting gluconeogenesis, as was characterized by the increased transcriptions of glut2, gk, and pk, and the decreased transcriptions of fbpase and g6pase. In addition, the supplementation of 120 mg/kg MgO NPs promoted Mg transport marked by a significant increase in the protein expressions of TRMP7, S41A3, and CNNM1. In conclusion, the moderate supplementation of MgO NPs improved the growth performance, reduced hepatic oxidative stress, and promoted glucose transport, glycolysis, glycogen synthesis, and magnesium homeostasis in fish while inhibiting glu.

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Section: Discussionmentioning

confidence: 99%

The Benefits of Nanosized Magnesium Oxide in Fish Megalobrama amblycephala: Evidence in Growth Performance, Redox Defense, Glucose Metabolism, and Magnesium Homeostasis

et al. 2023

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“…If the intake slightly exceeds the daily requirement, absorption of magnesium from the gut is reduced and its active renal secretion in the urine can exceed 100% of the filtered load [ 6 ]. Although an excess of magnesium from food does not represent a health risk in healthy individuals because the kidneys eliminate excess amounts in the urine [ 220 ], high doses of magnesium from dietary supplements, drugs, or other sources can often cause not only diarrhea accompanied by nausea and abdominal cramping but also the onset of diseases [ 221 ]. As previously reported, magnesium formulations most commonly associated with diarrhea, include magnesium carbonate, chloride, gluconate, and oxide [ 222 ].…”

Section: Nutritional Strategies To Avoid Magnesium Deficienciesmentioning

confidence: 99%

Magnesium: Biochemistry, Nutrition, Detection, and Social Impact of Diseases Linked to Its Deficiency

et al. 2021

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Magnesium plays an important role in many physiological functions. Habitually low intakes of magnesium and in general the deficiency of this micronutrient induce changes in biochemical pathways that can increase the risk of illness and, in particular, chronic degenerative diseases. The assessment of magnesium status is consequently of great importance, however, its evaluation is difficult. The measurement of serum magnesium concentration is the most commonly used and readily available method for assessing magnesium status, even if serum levels have no reliable correlation with total body magnesium levels or concentrations in specific tissues. Therefore, this review offers an overview of recent insights into magnesium from multiple perspectives. Starting from a biochemical point of view, it aims at highlighting the risk due to insufficient uptake (frequently due to the low content of magnesium in the modern western diet), at suggesting strategies to reach the recommended dietary reference values, and at focusing on the importance of detecting physiological or pathological levels of magnesium in various body districts, in order to counteract the social impact of diseases linked to magnesium deficiency.

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Severe Hypermagnesemia

Cited by 2 publications

References 0 publications

The Benefits of Nanosized Magnesium Oxide in Fish Megalobrama amblycephala: Evidence in Growth Performance, Redox Defense, Glucose Metabolism, and Magnesium Homeostasis

The Benefits of Nanosized Magnesium Oxide in Fish Megalobrama amblycephala: Evidence in Growth Performance, Redox Defense, Glucose Metabolism, and Magnesium Homeostasis

Magnesium: Biochemistry, Nutrition, Detection, and Social Impact of Diseases Linked to Its Deficiency

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