Severe Hyperferritinemia in Mycobacteria tuberculosis Infection

Visser, A T; Vyver, A. Van De

doi:10.1093/cid/ciq126

Cited by 29 publications

(21 citation statements)

References 10 publications

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“…The patient further improved in symptoms; it was not clear if this was attributed to the antibiotic coverage or the natural course of AOSD, however due to the negative workup of infectious etiology it is likely that the patient's improvement in symptoms was due to the natural course of the disease while on prednisone [18,19]. With the multiple negative acid fast stains and cultures of sputum to rule out Tuberculosis, the house Pulmonologist was not comfortable discharging the patient until definitively Tuberculosis was ruled out.…”

Section: Discussionmentioning

confidence: 99%

Non Infectious Cavitary Lung Lesions in a Patient with Adult Onset Still’s Disease: A Case Report

Mitchell¹,

Helen²

2017

J Infect Dis Preve

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Acute Onset Still's Disease (AOSD) is a disease of immunologic and hematologic dysfunction, whereby a percentage of cases develop further into Macrophage Activating Syndrome (MAS). This patient is a 35 year old Caucasian male with Acute Onset Still's Disease without MAS was hospitalized for multiple cavitary lung lesions. Lesions included a larger estimated 2.5 cm x 2.5 cm cavitary lesion in the Right Middle Lobe and smaller estimated 1.3 x 1.4 cm and 1.8 x 1.2 cm lesions in the Left Lower Lobe of the lungs. The larger lesion was seen on chest X-ray a further detailed on a chest CT scan, which revealed the remaining two smaller pulmonary lesions. The patient experienced undulating fevers as high as 101°F. The patient was put on isolation and received serial blood cultures, sputum cultures, acid fast stains of sputum, urine cultures, viral film array serology all resulting in negative results. Over seven acid fast bacilli stains of sputum were negative in the setting of multiple cavitary lung lesions with high suspicion of active Tuberculosis. The patient received immediate broad spectrum antibiotic and antifungal intravenous antibiotics without relief in fever or symptoms. The patient received a full body Indium scan and MRI of the brain looking for a source of possible infection and further classification of his disease; both of which were negative. The blood and sputum fungal and bacterial cultures were negative. Serial chest CT and chest X-ray demonstrated slightly smaller cavitary lung lesions with thinner walls. The suspicion of Tuberculosis remained high and a lung biopsy was obtained of the large cavitary lesion in the Left Middle Lobe, which did not demonstrate acid fast staining on three separate samples. This patient was concluded to have noninfectious cavitary lung lesions and discharged home with close follow up. He is the first patient reported with AOSD Disease without MAS hospitalized for undulating fevers and multiple cavitary lung lesions without evidence of Tuberculosis of active infection.

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Section: Discussionmentioning

confidence: 99%

Non Infectious Cavitary Lung Lesions in a Patient with Adult Onset Still’s Disease: A Case Report

Mitchell¹,

Helen²

2017

J Infect Dis Preve

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“…8 La ferritina puede elevarse en procesos inflamatorios agudos o crónicos. Visser et al, 9 observaron hiperferritininemia en pacientes con tuberculosis diseminada, especialmente en VIH positivos.…”

Section: Discussionunclassified

Síndrome hemofagocítico asociado a tuberculosis en una paciente con inmunodeficiencia adquirida

et al. 2016

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“…[13] Ferritin is also an acute phase protein, the levels of which are raised in both infectious and non-infectious causes. [10,15] One study from South Africa documented 19 patients with ferritin levels > 10,000 ng/mL, with TB appearing to be the most common cause, accounting for 42% of cases. [10] In the current study, the patients in both the TB and the control groups had raised ferritin levels, with those in the TB group being significantly higher than in the control group (P <0.01).…”

Section: Discussionmentioning

confidence: 99%

“…[7] However, despite such a high burden of TB, there have been surprisingly few studies describing the acute phase and stress hormone responses in the global context in patients with newly-diagnosed, active TB. [9][10][11][12][13] The aim of the current study was to document the acute phase response, and associated catecholamine/cortisol release, in patients with newly-diagnosed active pulmonary TB. We have compared these responses in the patients with TB to a control group of patients with an acute phase response elicited by conditions other than TB.…”

Section: Introductionmentioning

confidence: 99%

Acute Phase Proteins and Stress Hormone Responses in Patients with Newly Diagnosed Active Pulmonary Tuberculosis

Opolot

Theron

Feldman

2014

Lung

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Severe Hyperferritinemia in Mycobacteria tuberculosis Infection

Cited by 29 publications

References 10 publications

Non Infectious Cavitary Lung Lesions in a Patient with Adult Onset Still’s Disease: A Case Report

Non Infectious Cavitary Lung Lesions in a Patient with Adult Onset Still’s Disease: A Case Report

Síndrome hemofagocítico asociado a tuberculosis en una paciente con inmunodeficiencia adquirida

Acute Phase Proteins and Stress Hormone Responses in Patients with Newly Diagnosed Active Pulmonary Tuberculosis

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