Severe hemolytic anemia following high-dose intravenous immunoglobulin administration in a patient with Kawasaki Disease

Nakagawa, Masao; Watanabe, Noriko; Okuno, Masahiko; Kondo, Masanori; Okagawa, Hiroto; Taga, Takashi

doi:10.1002/(sici)1096-8652(200003)63:3<160::aid-ajh11>3.0.co;2-4

Cited by 36 publications

(21 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Anemia is not an infrequent finding in patients with KD and is associated with a more prolonged duration of active inflammation [3][4][5][6]. Severe hemolytic anemia requiring transfusions is rare and may be related to intravenous immunoglobulin (IVIG) infusion [4,5,7]. However, the underlying molecular mechanism of anemia in KD is still unknown [5,6].…”

supporting

confidence: 84%

Inflammation-Induced Hepcidin is Associated with the Development of Anemia and Coronary Artery Lesions in Kawasaki Disease

Kuo

Yang

Chuang³

et al. 2012

J Clin Immunol

View full text Add to dashboard Cite

show abstract

supporting

confidence: 84%

Inflammation-Induced Hepcidin is Associated with the Development of Anemia and Coronary Artery Lesions in Kawasaki Disease

Kuo

Yang

Chuang³

et al. 2012

J Clin Immunol

View full text Add to dashboard Cite

show abstract

“…Furthermore, Lin et al observed that hemoglobin is a useful marker for differentiating KD shock syndrome from toxic shock syndrome in a pediatric intensive care unit [25]. Although severe hemolytic anemia requiring transfusion is rare, it may be related to IVIG infusion [21,22,26]. The major causes of hemolysis are generally associated with anti-A and anti-B IgM antibodies, as well as the anti-Rh IgG antibody [27].…”

Section: Anemia In Patients With Kawasaki Diseasementioning

confidence: 99%

Anemia in Kawasaki Disease: Hepcidin as a Potential Biomarker

Huang

Kuo

2017

IJMS

View full text Add to dashboard Cite

Kawasaki disease (KD) is an autoimmune-like disease and acute childhood vasculitis syndrome that affects various systems but has unknown etiology. In addition to the standard diagnostic criteria, anemia is among the most common clinical features of KD patients and is thought to have a more prolonged duration of active inflammation. In 2001, the discovery of a liver-derived peptide hormone known as hepcidin began revolutionizing our understanding of anemia’s relation to a number of inflammatory diseases, including KD. This review focuses on hepcidin-induced iron deficiency’s relation to transient hyposideremia, anemia, and disease outcomes in KD patients, and goes on to suggest possible routes of further study.

show abstract

“…[27] Individual reports of acute haemolysis in children with KD treated with IVIG have been reported. [13,28] Our patient was treated with Gammagard® infusion and there are reports that this product has higher isohaemagglutinin titres than lyophilized ones. [29] Haemolysis after Gammagard® infusion is considered to be usually mild, but many patients require RBC transfusion, according to the overview of the literature covering not only KD patients.…”

Section: Case Discussionmentioning

confidence: 71%

“…There are not many reports of haemolytic anaemia after IVIG infusions, but paediatricians have to be aware of this complication especially in KD patients where some factors increase the risk of haemolysis. [12,13] Case report…”

Section: Ivig Treatment and Adverse Effectsmentioning

confidence: 99%

Kawasaki disease and acute haemolytic anaemia after two IVIG infusions

Telcharova-Mihaylovska

Stefanov

Nikolova

2016

Biotechnology & Biotechnological Equipment

View full text Add to dashboard Cite

Kawasaki disease (KD) is one of the most common vasculitis disorders of childhood, affecting predominantly medium-sized arteries, particularly the coronary arteries. For treatment, high-dose intravenous immunoglobulin (IVIG) is indicated. IVIG infusions are usually safe and well tolerated even though serious complications can be observed. We present a brief overview of KD and report a two-year-old girl with KD and two IVIG infusions (Gammagard®) because of persistent fever after the completion of the first IVIG. Haemolytic anaemia developed after IVIG retreatment. The direct antiglobulin test after haemolysis was positive. The etiology of the haemolysis was related to the presence of transient, passively acquired antibodies that cause a direct antibody-mediated attack. There are few reports of haemolytic anaemia after IVIG infusions. The haemolysis in KD is dosedependent and occurs more frequently after the second IVIG dose. Non-0 blood group patients are at greater risk. Another factor increasing the risk of haemolysis is also the presence of anaemia due to inflammation in KD.

show abstract

Severe hemolytic anemia following high-dose intravenous immunoglobulin administration in a patient with Kawasaki Disease

Cited by 36 publications

References 4 publications

Inflammation-Induced Hepcidin is Associated with the Development of Anemia and Coronary Artery Lesions in Kawasaki Disease

Inflammation-Induced Hepcidin is Associated with the Development of Anemia and Coronary Artery Lesions in Kawasaki Disease

Anemia in Kawasaki Disease: Hepcidin as a Potential Biomarker

Kawasaki disease and acute haemolytic anaemia after two IVIG infusions

Contact Info

Product

Resources

About