Severe headache as the sole presenting symptom of COVID-19 pneumonia: A case report

Kimambo, Henrika; Chin, Jerome H.; Mnacho, Mohammed; Punatar, Priyank; Msilanga, Daniel; Chagula, Anney Cletus

doi:10.1016/j.inat.2020.100882

Cited by 3 publications

(1 citation statement)

References 6 publications

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“…Left midbrain Case 6. Right side of the periventricular area 48 Novel coronavirus (COVID-19)-associated Guillain-BarrÃ© syndrome: case report [ 54 ] MRI—spine No evidence of myelopathy or radiculopathy 49 Olfactory gyrus intracerebral hemorrhage in a patient with COVID-19 infection [ 55 ] CT—head MRI—brain Right olfactory gyrus ICH with surrounding edema, with no evidence of soft tissue injury or cerebral contusion 50 Orbitofrontal involvement in a neuroCOVID-19 patient [ 56 ] MRI—brain Hyperintensity of the right orbital prefrontal cortex adjacent to the olfactory bulb, which seemed to spread toward the right caudate nucleus and mesial prefrontal cortex 51 Posterior reversible encephalopathy syndrome (PRES): another imaging manifestation of COVID-19 [ 57 ] CT—head MRI—brain Symmetric hypoattenuation of the external capsules and posterior subcortical cerebral white matter Hyperintensity with increased diffusion in the internal and external capsules, subcortical, deep cerebral, and cerebellar white matter 52 Prolonged confusional state as first manifestation of COVID-19 [ 6 ] CT—head Mild chronic small vessel ischemic changes 53 Reversible cerebral vasoconstriction syndrome and dissection in the setting of COVID-19 infection [ 58 ] CT—head B/L convexity SAH Left vertebral artery dissection 54 Reversible encephalopathy syndrome (PRES) in a COVID-19 patient [ 59 ] CT—head CTA MRI—brain Posterior frontal and temporo-parieto-occipital symmetrical B/L hypodensity of the subcortical white matter, and a small left occipital parenchymal hemorrhage Absence of vascular malformation and alterations of posterior circle vessel caliber- suggestive of vasoconstriction mechanism Onset of right temporal hypodensity, correlated to hemorrhagic process 55 SARS-CoV-2-associated Guillain-BarrÃ© syndrome with dysautonomia [ 60 ] CT—head No abnormalities 56 Severe headache as the sole presenting symptom of COVID-19 pneumonia: a case report [ 61 ] MRI—brain MRA Nonspecific white...…”

Section: Resultsmentioning

confidence: 99%

Neurological manifestations and neuroimaging findings in patients with SARS-CoV2—a systematic review

Mohan

Fayyaz

Rio

et al. 2021

Egypt J Neurol Psychiatry Neurosurg

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Background The COVID-19 pandemic has drastically affected everyone in a hit or miss manner. Since it began, evidence of the neuro-invasive potential of the virus has been intensifying significantly. Several pathways have been hypothesized to elucidate the neurotropic nature of SARS-CoV2. It is the need of the hour to collect vital information. Objective To evaluate and correlate the neuro-radiological and neurological manifestations in patients diagnosed with SARS-CoV2. To identify neuro-invasive pathways of COVID infection. Methods Relevant studies were identified through four databases—the Cochrane Library, PubMed, Science Direct, and Web of Science. These were searched using relevant keywords—“COVID-19,” “SARS-CoV2,” “neurological manifestations,” “neuroimaging,” “CT,” and “MRI.” Relevant articles were screened according to a pre-defined inclusion and exclusion criteria from December 2019 to August 2020. Results Our review included a total of 63 full text publications with 584 patients, composed mainly of observational studies, case reports, and case series. The most common neurological manifestations associated with COVID-19 were altered mental status, stroke, and paralysis. About 17.85% patients who underwent neuroimaging were found to be having ischemic changes suggestive of a stroke. This was followed by hemorrhagic changes as the second most common finding. The most commonly involved vessel was the Middle Cerebral Artery. Besides stroke, we found that SARS-CoV2 could be the cause for new-onset seizures, Guillain-Barre Syndrome, encephalitis, and many other severe neurological diseases. Conclusion The information that we have obtained so far will prove dynamic to healthcare providers working against the COVID-19 pandemic. It is necessary to be aware of these atypical neurological findings for the early diagnosis and treatment of COVID-19 infected patients. However, to completely understand the connection between SARS-CoV2 and the nervous system, further research is necessary.

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Section: Resultsmentioning

confidence: 99%

Neurological manifestations and neuroimaging findings in patients with SARS-CoV2—a systematic review

Mohan

Fayyaz

Rio

et al. 2021

Egypt J Neurol Psychiatry Neurosurg

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Neurological manifestations of COVID-19: a systematic review and detailed comprehension

Ousseiran

Fares

Chamoun

2021

International Journal of Neuroscience

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The current pandemic caused by severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) is accompanied with a rapid increase of reports and papers detailing its neurological effects and symptoms. The virus infection causes respiratory illness named by the world health organization as corona virus 19 (COVID-19).This systematic review aims to study and summarize the different neurological manifestations of this virus. All articles published and indexed via Pubmed, Medline and Google Scholar databases between January 1st 2020 and February 28th 2021 that reported neurological symptoms of SARS-CoV-2 are reviewed following the Preferred Reporting Items for Systemic review and Meta-Analysis (PRISMA) guidelines.We included data from 113 articles: eight prospective studies, 25 retrospective studies and the rest were case reports/series. COVID-19 can present with central nervous system manifestations, such as headache, encephalitis and encephalopathy, peripheral nervous system manifestations, such as anosmia, ageusia and Guillian Barre syndrome, and skeletal muscle manifestations, such as myalgia and myasthenia gravis. Our systematic review showed that COVID-19 can be manifested by a wide spectrum of neurological symptoms reported either in the early stage or within the course of the disease. However, a detailed comprehension of these manifestations is required and more studies are needed in order to improve our scientific knowledge and to develop preventive and therapeutic measures to control this pandemic.

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Neurological manifestations in patients with symptomatic COVID-19 admitted to the Bafoussam Regional Hospital, Cameroon

Fogang¹,

Noubom²,

Bassong³

et al. 2021

Pan Afr Med J

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Introduction although the main manifestations of COVID-19 are respiratory, several neurological symptoms and complications have also been reported. The pandemic seems to have some epidemiological specificities in sub-Saharan Africa, and this may be reflected in the type and frequency of neurological symptoms. This study aimed to report neurological manifestations associated with symptomatic COVID-19 in a sub-Saharan African setting. Methods we conducted a retrospective review of symptomatic PCR-confirmed COVID-19 cases admitted to the Bafoussam Regional Hospital between March and September 2020. Patients’ files were reviewed at discharge by a consultant neurologist. Socio-demographic characteristics, co-morbidities, symptoms on admission, neurological symptoms during hospitalization, management, and in-hospital outcome were recorded. Comparisons between patients with and without neurological symptoms were performed using Fisher’s exact and Mann-Whitney U test. Results we enrolled 177 symptomatic patients (68% men). Mean age was 54.6 ± 17.8 years (range 2-99 years). Co-morbidities were present in 57.6% of patients, including hypertension (27.1%) and diabetes mellitus (25.4%). Neurological symptoms were found in 113 (63.8%) patients. The most frequent were headache (39.0%), myalgia (35.6%), anosmia (11.9%), impaired consciousness (10.7%) and delirium (5.6%). Regarding the presenting symptoms, fever was more frequent in patients with neurological symptoms than in those without (81.4% versus 50.0%, p< 0.001), while digestive symptoms were less frequent in patients with neurological symptoms (0.9% versus 9.4%, p= 0.004). Conclusion neurological manifestations are frequent and heterogeneous in patients with symptomatic COVID-19. Further studies are needed to clarify the pathophysiology of neurological symptoms in COVID-19 and their impact on patients’ long-term outcome.

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Severe headache as the sole presenting symptom of COVID-19 pneumonia: A case report

Abstract: Highlights Neurologic symptoms including headache are reported in COVID-19 patients. Severe headache may be the sole presenting symptom of COVID-19 pneumonia. Headache may precede respiratory symptoms for up to one week in COVID-19.

Cited by 3 publications

References 6 publications

Neurological manifestations and neuroimaging findings in patients with SARS-CoV2—a systematic review

Neurological manifestations and neuroimaging findings in patients with SARS-CoV2—a systematic review

Neurological manifestations of COVID-19: a systematic review and detailed comprehension

Neurological manifestations in patients with symptomatic COVID-19 admitted to the Bafoussam Regional Hospital, Cameroon

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