“…In addition, a number of severe invasive GAS infections have been reported in North America, Europe, and Japan (2,18,30,34,36). These infections comprise a wide range of diverse diseases, including acute respiratory distress syndrome, renal failure, toxic shocklike syndrome (TSLS), sepsis, and cellulitis (2,18,35). Since infection can occasionally progress within hours to necrosis of an entire limb and lethal shock (2,18,35), GAS has become known as the "flesh-eating bug."…”