Severe generalized argyria secondary to ingestion of colloidal silver protein

White, J. M. L.; Powell, Ann‐Marie; Brady, Ken; Russell‐Jones, Robin

doi:10.1046/j.1365-2230.2003.01214.x

Cited by 103 publications

(124 citation statements)

References 9 publications

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“…The antifungal potential of AgNP shows coherence with broad spectrum activity, multiple cellular targets and minimum host toxicity. However, silver is reported to be toxic at a high concentration and its persistent use causes argyrosis and argia [9,10]. Therefore, the requirement is towards exploring novel biocompatible nanomaterials with effective anti-biofilm and optical properties.…”

Section: Discussionmentioning

confidence: 99%

Nano Based Therapy for Biofilm Management: Mini Review

Rawat¹

2017

JNMR

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High toxicity, low host tolerance, narrow spectrum of antifungal drugs and increasing incidence of azole-resistance complicates treatment of invasive Candida infections. Due to the emergence of antimicrobial resistance as an increasing threat to global health care, arises the need to develop new, and effective broad spectrum active antifungal agents. Thus understanding and combating drug resistance in Candida albicans is a toughest challenge being faced today and it's immensely important to develop an alternative coating that can inhibit biofilm formation on medical devices as implants and catheters. Additionally, the fascinating properties of nanomaterials and biocompatibility promises great potential in nanomedical applications, especially in medical microbiology. With appropriate modification of these synthetic materials, several disease infections can be cured and results have shown the use of these nanomaterials as diagnostic and immunotherapauetic agents. Since, antimicrobial resistance is becoming a major apprehension worldwide, nanomedicines offer an intriguing and promising solution for combating these high resistance pathogens by appropriate development of therauptic and novel diagnosis approaches. This mini review presents the current state of art in this emerging field.

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Section: Discussionmentioning

confidence: 99%

Nano Based Therapy for Biofilm Management: Mini Review

Rawat¹

2017

JNMR

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“…Thus, argyria as a result of taking silver-containing supplements has been reported many times. [5][6][7][8][9][10][11] Because of the striking appearance of the blue-grey discolouration of sun-exposed area, argyria is easily suspected clinically. However, causative agents should be confirmed by analysis of EDX through SEM examination.…”

Section: Discussionmentioning

confidence: 99%

Skin discolouration with acute onset parkinsonism secondary to systemic zirconium intoxication

et al. 2013

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A 72-year-old woman presented with suspected parkinsonism and discolouration of the skin especially on sun-exposed areas. Thorough investigation revealed systemic zirconium intoxication due to intake of metallic colloids as a home remedy as a cause of the skin colour change. There may be an association between skin discolouration and her parkinsonism. This is unique in that various clinical manifestations developed following systemic ingestion of zirconium and this should serve as a warning on the risk of taking illicit dietary supplements.

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“…This was probably because some of the A-type tissues resembled B-type tissue in the mid stage or that some sulfuration had occurred in the short term. Selenium, having the same chemical property as S, has been found to exist with Ag in pigmentation cases 13,28) . However, Se was not found in our experiment.…”

Section: Sulfuration Of Silvermentioning

confidence: 99%

“…In the case of argyria, White et al 13) demonstrated the presence of silver with S and Se in the base membrane and elastic fibers. Aoyagi and Katagiri 17) also reported the existence of silver and S in connective tissue without host reaction.…”

Section: Sulfuration Of Silvermentioning

confidence: 99%

“…While silver is well known to be cytotoxic 5,6,10,11) , it has historically been used as medicine for mental illness, epilepsy and infectious diseases, among others 12) . Currently, it is still being used as a supplement 12,13) . Moreover, with advances in nanotechnology, nanosilver 14,15) is applied for the preparation of many consumer goods, such as sanitization agents and deodorizers.…”

Section: Introductionmentioning

confidence: 99%

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Long-term Effect of Silver Powder in vivo

Aoyagi

Iwasaki

2008

Dent. Mater. J.

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The cytotoxicity of silver is a known property of this metal. Interestingly, in the cases of argyria and tattoos, Ag remains in the tissue for a long time without causing harm to the host except pigmentation. To understand these contradictions, pure silver implantation by an original subcutaneous injection method was performed. Two sizes of silver powder particles were implanted subcutaneously: 100 nm (P-silver) and the maximum 45 μm (G-silver). The sulfuration of silver and histopathologic changes were observed for a year. Results were as follows: silver affected the host in the case of P-silver to a greater extent than in G-silver, especially on the 7 th day and after 2 -4 weeks. Nonetheless, the effect of silver weakened at 12 months after implantation. The presence of P-silver caused various histological reactions, while the decline of silver effect on the host was correlated with an increase in the sulfuration of silver.

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Severe generalized argyria secondary to ingestion of colloidal silver protein

Cited by 103 publications

References 9 publications

Nano Based Therapy for Biofilm Management: Mini Review

Nano Based Therapy for Biofilm Management: Mini Review

Skin discolouration with acute onset parkinsonism secondary to systemic zirconium intoxication

Long-term Effect of Silver Powder in vivo

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