Severe frailty and cognitive impairment are related to higher mortality in 12-month follow-up of nursing home residents

Matusik, Paweł T.; Tomaszewski, Krzysztof A.; Chmielowska, Katarzyna; Nowak, Jan; Nowak, Wojciech; Parnicka, Agnieszka; Dubiel, Marzena; Gąsowski, Jerzy; Grodzicki, Tomasz

doi:10.1016/j.archger.2011.06.034

Cited by 85 publications

(53 citation statements)

References 16 publications

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“…Such patients are suffering from a considerable number of chronic illnesses (3.8 on average), the prevalence of FS and dementia reaches 80%, 15,25 and annual mortality is 28%. 26 Unexpectedly, there was no relationship between the presence of HF and OH.…”

mentioning

confidence: 99%

Heart failure, comorbidities, and polypharmacy among elderly nursing home residents

Michalik¹,

Matusik²,

Nowak³

et al. 2013

Polish Archives of Internal Medicine

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mentioning

confidence: 99%

Heart failure, comorbidities, and polypharmacy among elderly nursing home residents

Michalik¹,

Matusik²,

Nowak³

et al. 2013

Polish Archives of Internal Medicine

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“…Frailty and cognitive impairment together are associated with higher mortality values than either frailty or cognitive impairment alone. 10 Our results suggest that geriatric interventions are necessary to improve clinical outcomes for frail patients with DrD.…”

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confidence: 90%

Unsteady gait is a determinant for progression in frailty among the elderly

Nagai

Koshiba

Tanaka

et al. 2016

Geriatrics Gerontology Int

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Letter to the Editor s DM, especially less-well controlled glycemia, is associated with greater prevalence of frailty, consistent with the present findings. 4 In addition to hyperglycemia, inflammatory processes 6 and oxidative stress 7 are among the key physiological components that underlie frailty. In our previous studies, patients with DrD showed significantly higher peripheral inflammatory and oxidative stress markers than those with AD − DM or AD + DM. 8,9 Although the exact inflammatory and oxidative mechanisms that contribute to frailty remain unclear, increased inflammation and high oxidative stress are involved in the pathophysiology associated with frailty in patients with DrD. Frailty is associated with a greater risk for adverse health outcomes including falls, disability, institutionalization and death. Frailty and cognitive impairment together are associated with higher mortality values than either frailty or cognitive impairment alone. 10 Our results suggest that geriatric interventions are necessary to improve clinical outcomes for frail patients with DrD.

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“…Frailty can accelerate cognitive decline (51)(52)(53)(54)(56)(57)(58). When frailty is combined with dementia, the risk of all cause mortality is increased (59).…”

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confidence: 99%