Severe fever with thrombocytopenia syndrome bunyavirus-related human encephalitis

Cui, Ning; Liu, Rong; Lu, Qing‐Bin; Wang, Liyuan; Qin, Shu-Li; Yang, Zhen‐Dong; Zhang, Lu; Liu, Kun; Li, Hao; Zhang, Xiao-Ai; Hu, Jing S.; Wang, Jingyu; Liu, Wei; Cao, Wu‐Chun

doi:10.1016/j.jinf.2014.08.001

Cited by 84 publications

(119 citation statements)

References 15 publications

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“…A noteworthy difference is the high incidence of encephalitis in SFTS patients. A recent study reported that 19.1% of hospitalized SFTS patients had encephalitis, and that 44.7% of these patients died 2). We infer that SFTSV can infect the CNS, and thereby lead to a more serious or even fatal clinical outcome, probably through immunopathological damage 2)…”

Section: Discussionmentioning

confidence: 67%

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Spontaneous Acute Subdural Hemorrhage in a Patient with a Tick Borne Bunyavirus-Induced Severe Fever with Thrombocytopenia Syndrome

Yoo

Jang

et al. 2017

Korean J Neurotrauma

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We report the first case of severe fever with thrombocytopenia syndrome (SFTS) and a spontaneous acute subdural hematoma (SDH) in Korea. A 79-year-old male presented with fever and thrombocytopenia. On the third day of hospitalization, his mental changed from drowsy to semi-coma. Brain computed tomography indicated an acute subdural hemorrhage on the right convexity. He was given early decompressive craniectomy, but did not survive. Real-time reverse transcription polymerase chain reaction analysis of a blood sample indicated the presence of SFTS virus (SFTSV). This is the first reported case with intracranial hemorrhage and SFTS. This case report describes our treatment of a patient with acute SDH and an infection from a tick-borne species of Bunyaviridae.

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Section: Discussionmentioning

confidence: 67%

“…A recent study reported that 19.1% of 538 SFTS cases also had encephalitis, and that 44.7% of these patients died 2). But there have been no reports of SFTS cases with intracranial hemorrhage such as subdural hemorrhage (SDH), epidural hemorrhage, and intracerebral hemorrhage (ICH).…”

Section: Introductionmentioning

confidence: 99%

Spontaneous Acute Subdural Hemorrhage in a Patient with a Tick Borne Bunyavirus-Induced Severe Fever with Thrombocytopenia Syndrome

Yoo

Jang

et al. 2017

Korean J Neurotrauma

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“…A higher serum viral load; older age; decreased white blood cell counts, platelet counts, lymphocyte percentage, and albumin; and an elevated neutrophil percentage, AST, ALT, LDH, CK, ALP, GGT, BUN, and CREA were identified to be risk factors for death. [5–8] In addition, patients with acute lung injury/acute respiratory distress syndrome, central nervous system (CNS) symptoms, hemorrhagic manifestations, and disseminated intravascular coagulation are more likely to die. [9–11] The majority of these results are consistent with our findings by univariate regression analysis.…”

Section: Discussionmentioning

confidence: 99%

A simple and practical score model for predicting the mortality of severe fever with thrombocytopenia syndrome patients

Xiong

Zhang

et al. 2016

Medicine

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“…Since emerging in China in 2009, thousands of infections have been reported in humans throughout China, South Korea, and Japan. Upon zoonosis from ticks to humans, SFTSV causes thrombocytopenia, leukocytopenia, febrile illness, and in severe cases encephalitis (1)(2)(3). SFTSV belongs to the Bhanja phlebovirus serocomplex, and genomic analysis reveals that the virus has evolved extensively over the last 150 y, having diverged into at least five different clusters (4).…”

mentioning

confidence: 99%

Structure of a phleboviral envelope glycoprotein reveals a consolidated model of membrane fusion

Halldorsson

Behrens

Harlos

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

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An emergent viral pathogen termed severe fever with thrombocytopenia syndrome virus (SFTSV) is responsible for thousands of clinical cases and associated fatalities in China, Japan, and South Korea. Akin to other phleboviruses, SFTSV relies on a viral glycoprotein, Gc, to catalyze the merger of endosomal host and viral membranes during cell entry. Here, we describe the postfusion structure of SFTSV Gc, revealing that the molecular transformations the phleboviral Gc undergoes upon host cell entry are conserved with otherwise unrelated alpha-and flaviviruses. By comparison of SFTSV Gc with that of the prefusion structure of the related Rift Valley fever virus, we show that these changes involve refolding of the protein into a trimeric state. Reverse genetics and rescue of site-directed histidine mutants enabled localization of histidines likely to be important for triggering this pH-dependent process. These data provide structural and functional evidence that the mechanism of phlebovirushost cell fusion is conserved among genetically and pathophysiologically distinct viral pathogens.emerging virus | phlebovirus | viral membrane fusion | bunyavirus | structure

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Severe fever with thrombocytopenia syndrome bunyavirus-related human encephalitis

Cited by 84 publications

References 15 publications

Spontaneous Acute Subdural Hemorrhage in a Patient with a Tick Borne Bunyavirus-Induced Severe Fever with Thrombocytopenia Syndrome

Spontaneous Acute Subdural Hemorrhage in a Patient with a Tick Borne Bunyavirus-Induced Severe Fever with Thrombocytopenia Syndrome

A simple and practical score model for predicting the mortality of severe fever with thrombocytopenia syndrome patients

Structure of a phleboviral envelope glycoprotein reveals a consolidated model of membrane fusion

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