Severe Eosinophilia in an Infant With Congenital Acute Myeloid Leukemia With t(3;4;6)(q26;q25;q21): A Case Report

Harisi, Marieta; Douna, Varvara; Baka, Margarita; Servitzoglou, Marina; Kosmidi, Helen; Anastasiou, Theodora

doi:10.1097/mph.0b013e3181e40e1b

Cited by 3 publications

(1 citation statement)

References 19 publications

(21 reference statements)

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“…Initial symptoms that raised the attention of the physician and parents included cutaneous lesions (most common), hepatosplenomegaly, pallor, jaundice, epistaxis, nephromegaly, intracranial hemorrhage, fever, and abnormal PB counts. 8–61 Prenatal findings suggesting potential abnormalities included hydramnios and organ masses; 8…”

Section: Resultsmentioning

confidence: 99%

Analysis of 59 cases of congenital leukemia reported between 2001 and 2016

et al. 2019

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Congenital leukemia (CL), defined as manifestations of leukemia within the first 4 weeks of life, is a rare condition with an estimated incidence of only 1 to 5 per million live births. Despite extensive research and the clinical application of new therapies, the prognosis of CL remains poor. Few large-scale studies have investigated the factors affecting the outcomes of infants with CL. Here, we conducted a retrospective study and analysis of CL cases published in the English language from 1 January 2001 to 1 May 2016. Our goal was to provide updated information about this rare disease and to investigate factors that may affect the outcomes of patients with CL.

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Section: Resultsmentioning

confidence: 99%

Analysis of 59 cases of congenital leukemia reported between 2001 and 2016

et al. 2019

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Hypereosinophilia in Acute Lymphoblastic Leukemia: Two Cases with Review of Literature

Sahu

Malhotra

Khadwal

et al. 2014

Indian J Hematol Blood Transfus

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Eosinophilia is rare in acute leukemia at presentation. Discrete reports and case studies in recent years have created significant interest in the field of ''Acute leukemia with eosinophilia''. We herein present two cases of eosinophilia in association with acute lymphoblastic leukemia with brief review of literature in this field. First case is about 21--year-old female who presented with mediastinal mass along with leukocytosis and hypereosinophilia. On evaluation, she was found to have T cell acute lymphoblastic leukemia. After ruling out benign causes of eosinophilia, she was treated with modified BFM-90 protocol. Her eosinophilia resolved after 4 weeks of induction therapy. Second case is about 32-yearold male who was diagnosed as a case of mixed phenotype leukemia (B cell/myeloid type) along with severe eosinophilia. His hypereosinophilia finally resolved by week 16 of modified BFM-90 protocol. Diagnosing ALL is challenging when eosinophilia is the initial presentation. These two cases emphasize on the importance of considering ALL amongst one of the etiological causes of eosinophilia as delay in diagnosis endangers patient's life at risk. Also eosinophilia per se is an independent poor risk factor, hence prompt diagnosis and early treatment is the key in all such cases.

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Spontaneous Resolution of Hypereosinophilic Syndrome in an Infant Without Treatment

Herrero

Fuente²,

Aleo³

et al. 2012

Journal of Pediatric Hematology/Oncology

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We report on a 4-month-old boy with hypereosinophilic syndrome (HES) and spontaneous progressive resolution without treatment. Differential diagnosis excluded myeloproliferative, lymphocytic, familiar, associated, and overlap HES. The final diagnosis was undefined HES. Repeated measurements of blood eosinophil counts, monitoring of clonal T cells, and observation of skin lesions and organ involvement were carefully performed as an outpatient.

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Severe Eosinophilia in an Infant With Congenital Acute Myeloid Leukemia With t(3;4;6)(q26;q25;q21): A Case Report

Cited by 3 publications

References 19 publications

Analysis of 59 cases of congenital leukemia reported between 2001 and 2016

Analysis of 59 cases of congenital leukemia reported between 2001 and 2016

Hypereosinophilia in Acute Lymphoblastic Leukemia: Two Cases with Review of Literature

Spontaneous Resolution of Hypereosinophilic Syndrome in an Infant Without Treatment

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