Severe DRESS syndrome after carbamazepine intake in a case with multiple addictions: A case report

Abstract

A case is presented of a male with drug rash with eosinophilia and systemic symptoms (DRESS) syndrome induced by carbamazepine intake. The patient presented all the elements of DRESS syndrome: Skin reaction, fever, enlargement of the lymph nodes, increased eosinophils and lymphocytes, with associated organ dysfunctions. The patient was admitted with acute laryngeal edema and imminence of respiratory insufficiency. The escalation of symptoms for this syndrome is typical, even after the administering of the the culprit medicine has ceased. However, in this case, the most difficult aspect was the complex treatment scheme prior to admission. All medical compounds involved in the background treatment were substituted with other substances in order to control the immune response. Current knowledge regarding DRESS is reviewed and possible influence of various etiologies over the present case are discussed. Clinicians should be aware of this rare situation with life-threatening potential. We benefited from the advantage of reuniting the knowledge of a complex team of experts from various tertiary emergency units in Romania.

The Synthesis and Evaluation of Aminocoumarin Peptidomimetics as Cytotoxic Agents on Model Bacterial E. coli Strains

“…1 H NMR (400 MHz, CDCl 3 ) δ 8.27 (d, J = 9.0 Hz, 1H), 7.28 (d, J = 9.0 Hz, 1H), 2.72 (t, J = 7.3 Hz, 1H), 2.54 (t, J = 7.1 Hz, 1H), 2.15–2.04 (m, 1H); 13 C NMR (101 MHz, CDCl 3 ) δ 178.4, 170.4, 155.3, 125.2, 122.4, 33.2, 32.6, 19.5. NMRs are in accordance with the earlier literature reports [ 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 ].…”

Urban allergy review: Allergic rhinitis and asthma with plane tree sensitization (Review)

“…orientalis has also been studied in connection with urban pollution. Levels of Pla or 1 and Pla or 3 were considerably greater in pollen samples from highly polluted areas than in unpolluted areas, which can lead to an increase in the prevalence of allergic diseases, in a study realized in Mashhad, the second city as size in Iran (37,38). Platanus pollen allergenic protein (Pla a1, molecular weight of 18 kDa) increased in abundance following exposure to pollutant gases and vehicle exhaust particles in a study conducted in the town of Shanghai, China.…”

Respiratory allergies: Salicaceae sensitization (Review)

“…Notably, the clinical diagnosis may be complicated by associated pathology, such as diabetes and hepatitis C (50). Various medications can trigger violent immune response and accentuate previous chronic pathology (51,52). Allergies of the Salix family require further research of the innate interactions between lymphocytes (53).…”