Severe disturbance occurring during treatment for depression of a bulimic patient with fluoxetine

Review: Problems associated with long-term treatment with selective serotonin reuptake inhibitors

“…Cases of SSRI-induced suicidality (suicide attempts and suicidal ideation) have been reported in adults (Teicher, et al, 1990;Rothschild and Locke, 1991;Hawthorne and Lacey, 1992). The risk of suicidality has been shown to be modestly increased in adolescents and children participating in randomised, placebo-controlled trials (Hammad, et al, 2006).…”

The Treatment of Bulimia Nervosa: Which Regimen Is Most Efficacious? An Analysis of the Evidence for Physician Assistants and Primary Care Providers Treating Eating Disorders

“…ideation in a depressed bulimic woman (Hawthorne & Lacey, 1992). However, a placebo-controlled study by Rampey et al (1992) of 785 bulimic women, 16.9% of whom were depressed, contradicts the association between fluoxetine and suicidality, reporting that a significantly greater proportion of fluoxetine-treated than placebo-treated patients actually displayed decreased suicidal ideation.…”

“…Tricyclics may have higher risk if used for suicide. Fluoxetine has now been investigated as a treatment for bulimia in several studies (Fichter et al, 1991;Fluoxetine Study Group, 1992;Goldbloom & Kennedy, 1991;Hawthorne & Lacey, 1992;Marcus et al, 1990;Oliveros et al, 1992;Ramirez et al, 1990;Solyom et al, 1990;Trygstad, 1990) with varying results. Many studies must be interpreted with caution because of the methods by which they were conducted.…”