Severe cutaneous aspergillosis in a premature neonate linked to nonsterile disposable glove contamination?

Stock, Claire; Veyrier, Magali; Rabérin, H.; Fascia, Pascal; Rayet, I; Lavocat, Marie Pierre; Teyssier, G; Berthelot, Philippe

doi:10.1016/j.ajic.2011.05.013

Cited by 13 publications

(13 citation statements)

References 9 publications

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“…Following one week of use, glove samples obtained from two different models of dispensing boxes showed much higher CFU counts than either of these earlier studies. 5,9,10 However, our study, in addition to acute care hospitals, also included a dental office and commercial enterprises with frequent use of gloves, including a funeral parlour and a tattoo art shop. Interestingly, the lowest mean CFU counts per glove over the 6-week observation period were found on gloves situated in a cleanroom, gowning area of an operation theatre (HD boxes: 1.9 CFU/ glove; TD boxes: 4.5 CFU/ glove), and the highest CFU counts per glove in a dental office (HD boxes: 319 CFU/glove; TD boxes: 685 CFU/glove).…”

Section: Discussionmentioning

confidence: 99%

Can the design of glove dispensing boxes influence glove contamination?

Assadian

Leaper

Krämer

et al. 2016

Journal of Hospital Infection

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Section: Discussionmentioning

confidence: 99%

Can the design of glove dispensing boxes influence glove contamination?

Assadian

Leaper

Krämer

et al. 2016

Journal of Hospital Infection

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“…Outbreaks of aspergillus infections in neonatal intensive care units (NICUs) have been reported in association with humidifying chambers of incubators, adhesive taping, gauze and non-sterile gloves as possible reservoirs 5 6. Singer et al 7 describe an outbreak of aspergillosis in a NICU in which three of four infected preterm infants died due to secondary systemic infection.…”

Section: Discussionmentioning

confidence: 99%

Primary cutaneous aspergillosis in a preterm neonate

Rogdo¹,

Kahlert

Diener

et al. 2014

BMJ Case Reports

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SUMMARYPrimary cutaneous aspergillosis (PCA) is a rare fungal infection in premature infants. Extreme prematurity, immature immune system, therapy with broad-spectrum antibiotics and systemic steroids, as well as hyperglycaemia and a vulnerable and very thin epidermal layer are considered risk factors in this patient population. We present a premature male infant born at 24 +3 weeks of gestation with PCA, successfully treated with amphotericin and surgical curettage of the ulcerating skin lesions. Complete resolution of the lesions was achieved and scarring was barely visible at later follow-up. BACKGROUND

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“…If non-sterile gloves are used, perforations may be more common with vinyl compared with latex gloves [51–53]. Non-sterile gloves may be more prone to fungal contamination compared with individually sealed sterile gloves [54]. …”

Section: Reviewmentioning

confidence: 99%

Endophthalmitis following intravitreal anti-vascular endothelial growth factor (VEGF) injection: a comprehensive review

Merani

Hunyor

2015

Int J Retin Vitr

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The purpose of this review is to report and summarize previously reported studies and assess many of the individual steps of the intravitreal injection procedure’s possible effect on the prevention of endophthalmitis. The pooled endophthalmitis rate from 20 large retrospective case series of anti-VEGF injections was 144/510,396 (0.028%; 1/3,544). Injections may be performed in an office-based location or in an operating room (OR) and low rates of endophthalmitis can be achieved in either location with careful attention to asepsis. Pre- or post-injection topical antibiotics have not been shown to be effective, and could select for more virulent microorganisms. Povidone-iodine prior to injection is accepted as the gold-standard antiseptic agent, but aqueous chlorhexidine may be an alternative. Antisepsis before and after gel or subconjunctival anesthetic is suggested. The preponderance of Streptococcal infections after intravitreal injection is discussed, including the possible role of aerosolization, which can be minimized by using face masks or maintaining silence. As with other invasive procedures in medicine, the use of sterile gloves, following adequate hand antisepsis, may be considered. Control of the eyelashes and lid margin is required to avoid contamination of the needle, but this can be achieved with or without a speculum. Techniques to minimize vitreous reflux have not been shown to reduce the risk of endophthalmitis. Same day bilateral injections should be performed as two separate procedures, preferably using drug from different lots, especially when using compounded drugs.

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Severe cutaneous aspergillosis in a premature neonate linked to nonsterile disposable glove contamination?

Cited by 13 publications

References 9 publications

Can the design of glove dispensing boxes influence glove contamination?

Can the design of glove dispensing boxes influence glove contamination?

Primary cutaneous aspergillosis in a preterm neonate

Endophthalmitis following intravitreal anti-vascular endothelial growth factor (VEGF) injection: a comprehensive review

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