Severe Crohn Disease of the Lung Following Colectomy

Mahgoub, Linda; Puntis, John; Chetcuti, Philip; Sugarman, Ian

doi:10.1097/mpg.0b013e318031c7f0

Cited by 5 publications

(5 citation statements)

References 23 publications

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“…The keywords "pediatric", "Crohn's disease", and "pulmonary" were used to retrieve the associated literature from PubMed, and the reference lists of these identified studies were checked. The review identified 22 cases of CD with pulmonary involvement (6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24), which consisted of 10 males and 12 females, and the ratio of males to females was 1:1.2. The clinical manifestations, chest radiological features, and histological manifestations of these cases are summarized in Table 3.…”

Section: Discussionmentioning

confidence: 99%

Crohn’s disease with pulmonary granuloma in a child: a case report and review of the literature

Cao¹,

Deng²,

Che³

et al. 2021

Transl Pediatr

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Crohn's disease (CD) is a complex, multifactorial disease that is characterized by chronic inflammation of the gastrointestinal system (1). It may affect any part of the gastrointestinal tract from the mouth to the anus. Approximately 25-40% of patients with CD can have multiple extraintestinal manifestations, including erythema nodosum, pyoderma gangrenosum, ankylosing spondylitis, arthritis, hepatitis, sclerosing cholangitis, pancreatitis, nephrolithiasis, uveitis, and episcleritis (2). The first report of lung involvement in CD was published in 1976 (3). The bronchopulmonary manifestations of CD are very rare extraintestinal manifestations, and the literature reports that the prevalence of these manifestations is as low as 0.2% (4). However, this prevalence rate may be underestimated, as an increasing number of cases have reported that the pulmonary performance of adult CD patients may be higher than was previously thought. Reports of children with CD involving the lungs are even rarer; thus, lung lesions are often overlooked. This article reports of one pediatric CD patient presenting

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Section: Discussionmentioning

confidence: 99%

Crohn’s disease with pulmonary granuloma in a child: a case report and review of the literature

Cao¹,

Deng²,

Che³

et al. 2021

Transl Pediatr

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“…[ 2 ] The clinical spectrum is wide from subclinical alterations, airway, and parenchymal disease to pleural disease or drug-induced disease. [ 1 6 ] Asymptomatic pulmonary involvement has been widely reported. [ 7 ] Pulmonary function tests (PFTs) are recommended;[ 5 ] decreased diffusing capacity and restrictive pattern in pulmonary functions along with bronchial hyperresponsiveness (BHR) even in the absence of clinical evidence have been documented at all ages.…”

Section: Discussionmentioning

confidence: 99%

“…[ 9 ] Our patient's HRCT result was consistent with the literature; since bronchial wall thickening, bronchiectasia, cysts, emphysema, ground-glass, and reticulonodular opacities can be observed in HRCT. [ 6 ] The bronchoalveolar lavage (BAL) studies point out neutrophilic or lymphocytic inflammation in the bronchi and alveoli of the patients. [ 6 ] We could not examine BAL due to parental disapproval for broncoscopy, nevertheless, the cytological evaluation of the deep tracheal aspirations obtained from our patient, which demonstrated neutrophilia consisted with inflammation in the lungs.…”

Section: Discussionmentioning

confidence: 99%

“…[ 6 ] The bronchoalveolar lavage (BAL) studies point out neutrophilic or lymphocytic inflammation in the bronchi and alveoli of the patients. [ 6 ] We could not examine BAL due to parental disapproval for broncoscopy, nevertheless, the cytological evaluation of the deep tracheal aspirations obtained from our patient, which demonstrated neutrophilia consisted with inflammation in the lungs. Since CRP is a well-known marker for disease activity in inflammatory bowel disease,[ 10 ] a rapid ameliorate in CRP after initiation of prednisolone, which is accepted as a treatment option in CD,[ 1 ] has led us to think the inflammation might be the result of a CD-associated pulmonary disease.…”

Section: Discussionmentioning

confidence: 99%

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A rare aspect of Crohn\'s disease: Pulmonary involvement in a child

Ongun

Artan

Bingöl

et al. 2016

Indian Journal of Critical Care Medicine

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Crohn's disease (CD), known as the disease of gastrointestinal system, is a granulamatous systemic disorder with extraintestinal manifestations including the respiratory system. The resemblance in the embriological origins and the immunities of both organ systems' mucosae, also the circulating immune complexes and the autoantibodies are accepted as contributing factors. The shift of inflammation may become prominent when the colon is removed after colectomy and independent of the bowel disease activity; pulmonary involvement may be exarbecated. In the pediatric population, CD associated pulmonary involvement is very rare, mainly in the form of subclinical alterations and the data are limited mostly to case reports. Therefore, it is possibly overlooked since the diagnosis relies on suspicion. We represent a 5-year-old CD patient with previous bronchiolitis episodes that might have resulted from CD-associated pulmonary involvement; whom later developed severe pneumonia resulting in acute respiratory distress syndrome and bronchiectasia following a colectomy operation.

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“…She was unresponsive to antibiotics but improved with infliximab therapy [13]. Seven of the 16 patients had cryptogenic organising pneumonia [22][23][24][25][26][27]. Two of these had interstitial pulmonary fibrosis [22,24].…”

Section: Pulmonary Parenchymal Diseasementioning

confidence: 99%

Inflammatory bowel disease and the lung in paediatric patients

Jochmann

Trachsel

Hammer

2021

Breathe

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The prevalence of inflammatory bowel disease (IBD) has increased over the past 20 years. Pulmonary involvement in paediatric IBD is rare but may be missed since the spectrum of symptoms is broad and mimics other diseases. The most important differential diagnoses of pulmonary manifestations of IBD are infections and therapy-related side-effects. There is no gold standard to diagnose respiratory manifestations in children with IBD. Diagnostic tests should be chosen according to history and clinical presentation. Treatment of respiratory manifestations of IBD includes inhaled or oral corticosteroids and initiation or step-up of immunomodulatory IBD therapies.

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Severe Crohn Disease of the Lung Following Colectomy

Cited by 5 publications

References 23 publications

Crohn’s disease with pulmonary granuloma in a child: a case report and review of the literature

Crohn’s disease with pulmonary granuloma in a child: a case report and review of the literature

A rare aspect of Crohn\'s disease: Pulmonary involvement in a child

Inflammatory bowel disease and the lung in paediatric patients

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