2022
DOI: 10.3390/cells11050847
|View full text |Cite
|
Sign up to set email alerts
|

Severe COVID-19 Shares a Common Neutrophil Activation Signature with Other Acute Inflammatory States

Abstract: Severe COVID-19 patients present a clinical and laboratory overlap with other hyperinflammatory conditions such as hemophagocytic lymphohistiocytosis (HLH). However, the underlying mechanisms of these conditions remain to be explored. Here, we investigated the transcriptome of 1596 individuals, including patients with COVID-19 in comparison to healthy controls, other acute inflammatory states (HLH, multisystem inflammatory syndrome in children [MIS-C], Kawasaki disease [KD]), and different respiratory infectio… Show more

Help me understand this report
View preprint versions

Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

2
28
0

Year Published

2022
2022
2023
2023

Publication Types

Select...
7

Relationship

2
5

Authors

Journals

citations
Cited by 31 publications
(35 citation statements)
references
References 125 publications
2
28
0
Order By: Relevance
“…Bergamaschi et al (2021) also identified IL-6 persistence in severe disease, along with the TNF-a. In contrast, other studies have shown that disease severity was related to elevated levels of myeloid chemoattractants and neutrophil activation (Freire et al, 2021;Szabo et al, 2021;Schimke et al, 2022). Possible differences in results (molecular profiles) observed between different studies may be due to differences in methods used for investigation, different times of sample collection during infection, or even due to differences in the immunogenetic background of the investigated population.…”
Section: Discussionmentioning
confidence: 92%
See 2 more Smart Citations
“…Bergamaschi et al (2021) also identified IL-6 persistence in severe disease, along with the TNF-a. In contrast, other studies have shown that disease severity was related to elevated levels of myeloid chemoattractants and neutrophil activation (Freire et al, 2021;Szabo et al, 2021;Schimke et al, 2022). Possible differences in results (molecular profiles) observed between different studies may be due to differences in methods used for investigation, different times of sample collection during infection, or even due to differences in the immunogenetic background of the investigated population.…”
Section: Discussionmentioning
confidence: 92%
“…Therefore, understanding the biological basis of long COVID-19 will allow us to identify factors that predispose to the development of long-term complications and guide effective therapies. In this sense, several studies have been developed, such as the REACT-GE study (in partnership with Genomics England) that aims to look for biological signatures that may be linked to the development of long COVID-19 and whether genes affect the severity of the COVID-19 and its long-term progression (Post-COVID-19 syndrome: in it for the long haul, 2021) Some studies have evaluated the molecular signature of acute COVID-19 cytokines by different methodologies (Bergamaschi et al, 2021;Freire et al, 2021;Szabo et al, 2021;Schimke et al, 2022). In our study, IL-6 levels were associated with the severe form of acute COVID-19.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…From a pathophysiological standpoint, the dysfunction of both the innate and adaptive immune responses characterize patients with severe COVID-19 [ 74 , 75 ]. Although increased neutrophils and neutrophil-to-lymphocyte ratio have been described in cases of severe COVID-19 [ 38 , 76 ], the active role of neutrophils in COVID-19 pathophysiology has been debated [ 77 ].…”
Section: Discussionmentioning
confidence: 99%
“…Plaça showcased the overlap in immunological signaling pathways between COVID-19 and hemophagocytic lymphohistiocytosis (HLH) [ 77 ]. This reflected on the fact that a common dysregulated neutrophil-associated gene signature reflected a generalized hyperinflammatory states and associated with COVID-19 severity [ 78 ]. Finally, Kasperkiewicz in a systemic literature review emphasized that awareness of rare post-COVID-vaccine autoimmune bullous disease (AIBD) could prove vital to the patients management.…”
Section: Covid-19 and Related Topics During Auto13mentioning
confidence: 99%