Severe COVID-19 pneumonia leads to post-COVID-19 lung abnormalities on follow-up CT scans

Hino, Takuya; Nishino, Mizuki; Valtchinov, Vladimir I.; Gagne, Staci; Gay, Elizabeth; Wada, Noriaki; Tseng, Shu Chi; Madore, Bruno; Ishigami, Kousei; Li, Yang; Christiani, David C.; Hunninghake, Gary M.; Levy, Bruce D.; Kaye, Kenneth M.; Hatabu, Hiroto

doi:10.1016/j.ejro.2023.100483

Cited by 6 publications

(1 citation statement)

References 27 publications

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“…32,33 Although fever, cytopenias, and pulmonary infiltrates are common features of SARS-CoV-2 infection, serositis and renal involvement is rather uncommon for a viral infection. Post-SARS-CoV2 pulmonary abnormalities that include organizing pneumonia has been reported in up to one-third of patients, 34 which is difficult to differentiate from pneumonitis caused by SLE. The high prevalence of the anti-dsDNA antibodies is also characteristic of these de novo SLE cases.…”

Section: Discussionmentioning

confidence: 99%

De novo lupus nephritis after SARS-CoV-2 infection

Mok

Chu

Tse

2023

Lupus

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The relationship between viral infection and onset of autoimmune diseases such as systemic lupus erythematosus remains uncertain. During the COVID-19 pandemic, organ-specific and multisystemic autoimmune phenomena temporally related to the viral infection have been described. Immune dysregulation triggered by the SARS-CoV-2 virus leading to hyperactivation of both the innate and adaptive immune systems contributes to the excessive production of pro-inflammatory cytokines, autoantibodies, and subsequent autoimmune manifestations. We report two patients without known autoimmune diseases who developed lupus nephritis shortly after a documented mild SARS-CoV-2 infection. Together with other similar cases in the literature, the observation supports a viral trigger of the development of systemic lupus erythematosus in susceptible individuals.

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Section: Discussionmentioning

confidence: 99%