Severe COVID‐19 in a pregnant patient admitted to hospital in Wuhan

Yu, Ying; Fan, Cuifang; Bian, Junmei; YinShen,

doi:10.1002/ijgo.13232

Cited by 9 publications

(16 citation statements)

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“…The meta-analysis was based on 745 COVID infected cases and 219 controls. A total of 34 case reports [ [55] , [56] , [57] , [58] , [59] , [60] , [61] , [62] , [63] , [64] , [65] , [66] , [67] , [68] , [69] , [70] , [71] , [72] , [73] , [74] , [75] , [76] , [77] , [78] , [79] , [80] , [81] , [82] , [83] , [84] , [85] , [86] , [87] , [88] ] yielding 45 cases were also included in the descriptive data analysis. Majority of the studies (12/34) were from China, 7 from the USA [ 62 , 67 , 68 , 70 , 76 , 85 , 87 ], 2 from Iran [ 63 , 80 ], 2 from Netherlands [ 82 , 83 ], 1 from Peru [ 75 ], 1 from Italy 1 [ 84 ], 1 from Sweden [ 64 ], 1 from Spain [ 73 ], 1 from Korea [ 55 ], 1 from Turkey [ 56 ], 1 from UK [ 78 ], 1 from Australia [ 88 ], 1 from Canada [ 79 ], 1 from Jordon [ 86 ], and 1 from India [ 72 ].…”

Section: Resultsmentioning

confidence: 99%

Maternal and neonatal characteristics and outcomes among COVID-19 infected women: An updated systematic review and meta-analysis

Dubey

Reddy

Manuel

et al. 2020

European Journal of Obstetrics & Gynecology and Reproductiv

157

135

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Objective Coronavirus disease 2019 (COVID-19) has become a global pandemic and may adversely affect pregnancy outcomes. We estimated the adverse maternal and neonatal characteristics and outcomes among COVID-19 infected women and determined heterogeneity in the estimates and associated factors. Study Designs PubMed search was performed of confirmed COVID-19 pregnant cases and related outcomes were ascertained prior to July 8, 2020, in this systematic review and meta-analysis. Studies reporting premature birth, low birth weight, COVID-19 infection in neonates, or mode of delivery status were included in the study. Two investigators independently performed searches, assessed quality of eligible studies as per the Cochrane handbook recommendations, extracted and reported data according to PRISMA guidelines. Pooled proportions of maternal and neonatal outcomes were estimated using meta-analyses for studies with varying sample sizes while a systematic review with descriptive data analysis was performed for case report studies. Maternal and neonatal outcomes included C-section, premature birth, low birth weight, adverse pregnancy events and COVID transmission in neonates. Results A total of 790 COVID-19 positive females and 548 neonates from 61 studies were analyzed. The rates of C-section, premature birth, low birth weight, and adverse pregnancy events were estimated as 72 %, 23 %, 7 %, and 27 % respectively. In the heterogeneity analysis, the rate of C-section was substantially higher in Chinese studies (91 %) compared to the US (40 %) or European (38 %) studies. The rates of preterm birth and adverse pregnancy events were also lowest in the US studies (12 %, 15 %) compared to Chinese (17 %, 21 %), and European studies (19 %, 19 %). In case reports, the rates of C-section, preterm birth, and low birth weight were estimated as 69 %, 56 %, and 35 %, respectively. Adverse pregnancy outcomes were associated with infection acquired at early gestational ages, more symptomatic presentation, myalgia symptom at presentation, and use of oxygen support therapy. Conclusions Adverse pregnancy outcomes were prevalent in COVID-19 infected females and varied by location, type, and size of the studies. Regular screening and early detection of COVID-19 in pregnant women may provide more favorable outcomes.

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Section: Resultsmentioning

confidence: 99%

Maternal and neonatal characteristics and outcomes among COVID-19 infected women: An updated systematic review and meta-analysis

Dubey

Reddy

Manuel

et al. 2020

European Journal of Obstetrics & Gynecology and Reproductiv

157

135

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“…independently. A total of 70 studies met the inclusion criteria [ 5 , 7 , 9 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , <...>…”

Section: Resultsunclassified

“…The distribution of studies in terms of quality of evidence based on GRADE are as follows: High quality ( n = 1) [ 41 ], moderate quality ( n = 11) [ 9 , 21 , 22 , 33 , 48 , 49 , 50 , 52 , 55 , 63 , 68 ], low quality ( n = 26) [ 5 , 9 , 23 , 24 , 25 , 26 , 28 , 29 , 36 , 40 , 43 , 46 , 47 , 51 , 54 , 56 , 60 , 61 , 62 , 64 , 65 , 66 , 67 , 69 , 70 , 73 ], and very low quality ( n = 32) [ 7 , 18 , 20 , 27 , 30 , 31 , 32 , 34 , 35 , 37 , 38 , 39 ,…”

Section: Resultsmentioning

confidence: 99%

“…Of the 70 studies included, 34 were carried out in China [ 5 , 9 , 25 , 26 , 27 , 28 , 30 , 31 , 32 , 42 , 43 , 44 , 45 , 46 , 47 , 53 , 54 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 73 , 78 ], 10 in the United States [ 21 , 22 , 23 , 37 , 48 , 49 , 52 , 75 , 79 , 85 ], eight in Italy [ 24 , 33 , 51 , 55 , 81 , 82 , 83 , 84 ], three in Iran [ 36 ,…”

Section: Resultsmentioning

confidence: 99%

“…Among pregnant women diagnosed with COVID-19, 68 (4.6%) were admitted in intensive care units (ICU) [ 21 , 22 , 23 , 33 , 36 , 55 , 56 , 67 , 85 ]. There were 15 (1.0%) cases of maternal death [ 21 , 36 , 39 , 41 ], mostly from United Kingdom ( n = 5) [ 41 ] and Iran ( n = 7) [ 36 ].…”

Section: Resultsmentioning

confidence: 99%

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Maternal Coronavirus Infections and Neonates Born to Mothers with SARS-CoV-2: A Systematic Review

et al. 2020

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The coronavirus disease 2019 (COVID-19) pandemic is continuously affecting the lives of all people. Understanding the impact of COVID-19 on pregnancy in terms of morbidity, mortality, and perinatal maternal and fetal outcomes is essential to propose strategies for prevention and infection control. Here, we conducted a systematic review to investigate pregnant women infected with COVID-19 in terms of signs and symptoms, type of delivery, comorbidities, maternal and neonatal outcomes, and the possibility of vertical transmission. A search on Embase and PubMed databases was performed on 31 October 2020. Observational studies and case reports on pregnant women infected with COVID-19 were included without language restrictions. The 70 selected studies included a total of 1457 pregnant women diagnosed with COVID-19 in the first, second, and third trimesters of pregnancy. The most common signs and symptoms were fever, cough, and nausea. The most frequent comorbidities were obesity, hypertensive disorders, and gestational diabetes. Among maternal and fetal outcomes, premature birth (n = 64), maternal death (n = 15), intrauterine fetal death or neonatal death (n = 16), cases of intrauterine fetal distress (n = 28), miscarriage (n = 7), decreased fetal movements (n = 19), and severe neonatal asphyxia (n = 5) were the most frequent. Thirty-nine newborns tested positive for SARS-CoV-2. Additionally, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA was detected in the placenta (n = 13) and breast milk (n = 6). This review indicates that COVID-19 during pregnancy can result in maternal, fetal, and neonatal complications. In addition, SARS-CoV-2 viral exposure of neonates during pregnancy and delivery cannot be ruled out. Thus, we highlight the need for long-term follow-up of newborns from mothers diagnosed with COVID-19 to establish the full implications of SARS-CoV-2 infection in these children.

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A Comprehensive Analysis of Maternal and Newborn Disease and Related Control for COVID-19

Cimolai

2021

SN Compr. Clin. Med.

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The maternal-fetal/newborn unit is established at risk for COVID-19 infection. This narrative review summarizes the contemporary and cumulative publications which detail maternal infection, antenatal and newborn infections, and maternal/fetal/newborn management and prevention. There is a wide spectrum of maternal disease, but the potential for severe disease albeit in a minority is confirmed. COVID-19 carries risk for preterm delivery. Pregnant females can suffer multisystem disease, and co-morbidities play a significant role in risk. Congenital infection has been supported by several anecdotal reports, but strong confirmatory data are few. No typical congenital dysmorphisms are evident. Nevertheless, placental vascular compromise must be considered a risk for the fetus during advanced maternal infections. Clinical manifestations of newborn infection have been mild to moderate and relatively uncommon. Proven antiviral therapy is of yet lacking. The mode of delivery is a medical decision that must include patient risk assessment and patient directives. Both presymptomatic and asymptomatic mothers and offspring can complicate infection control management with the potential for spread to others in several regards. In the interim, infections of the maternal-fetal-newborn unit must be taken seriously both for the disease so caused and the potential for further dissemination of disease.

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Severe COVID‐19 in a pregnant patient admitted to hospital in Wuhan

Abstract: A case report describing severe COVID‐19 and treatment strategy in a pregnant patient who delivered vaginally at 34 weeks.

Cited by 9 publications

References 1 publication

Maternal and neonatal characteristics and outcomes among COVID-19 infected women: An updated systematic review and meta-analysis

Maternal and neonatal characteristics and outcomes among COVID-19 infected women: An updated systematic review and meta-analysis

Maternal Coronavirus Infections and Neonates Born to Mothers with SARS-CoV-2: A Systematic Review

A Comprehensive Analysis of Maternal and Newborn Disease and Related Control for COVID-19

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