Severe Constipation in Parkinson's Disease and in Parkinsonisms: Prevalence and Affecting Factors

Frazzitta, Giuseppe; Ferrazzoli, Davide; Folini, Annarita; Palamara, Grazia; Maestri, Roberto

doi:10.3389/fneur.2019.00621

Cited by 30 publications

(25 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although we did not complete a statistical analysis of Medopa dosage alone, this study showed no difference between LEDs in Cons-PD and nCons-PD groups, being consistent with Frazzitta et al (28) but contrary to Zhang and Liu's (29) findings. The possible lack of correlation between LED and constipation is worthy of consideration as some authors have previously attributed constipation to dopaminergic treatment (30).…”

Section: Discussionsupporting

confidence: 87%

Depression Is Associated With Constipation in Patients With Parkinson's Disease

Qin

Chen

Lü³

et al. 2020

Front. Neurol.

View full text Add to dashboard Cite

Objective: Constipation is one of the most frequent non-motor symptoms (NMS) in Parkinson's disease (PD), causing great disturbance to patients. The present study investigated the prevalence and the clinical features of constipation in patients with PD and explored the difference between prodromal and clinical constipation of PD.Methods: A total of 186 patients with PD were recruited into this study. Subjective constipation was defined by ROME III criteria. Demographic and PD-related clinical information of the participants were collected. The PD patients were objectively assessed by a spectrum of rating scales of motor symptoms, non-motor symptoms, and quality of life.Results: In total, 51.61% (96/186) of PD patients suffer from constipation. Compared with patients without constipation, the patients with constipation were prone to have restless leg syndrome, depression, and anxiety and have higher scores of the non-motor symptoms scale. Among patients with constipation, 21.88% (21/96) patients had constipation in prodromal stage. Compared with patients with constipation in clinical stage, patients with prodromal constipation had a lower age of constipation onset (56.48 ± 9.63 and 65.26 ± 8.42, χ2 = 4.091, P < 0.001), longer timespan from constipation onset to motor symptom onset (6.62 ± 3.91 and 3.18 ± 2.13, χ2 = −3.877, P = 0.001). Patients with prodromal constipation were predominantly tremor onset (χ2 = 4.405, P = 0.044) and usually had a better quality of life [28 (14.50–37.5) and 40 (25.0–55.0), χ2 = 2.011, P = 0.046]. Depression was the only risk factor of constipation in PD patients. Body mass index, depression, and anxiety were factors that affected the life quality in patients with constipation.Conclusions: Our results supported the high incidence of constipation in patients with PD and that, in some patients, constipation occurred before the onset of motor symptoms. The specific clinical characteristics of patients with constipation and with prodromal constipation help to make early diagnosis, to discover the relationship between constipation and PD, and to further explore the pathogenesis of this degenerative disease.

show abstract

Section: Discussionsupporting

confidence: 87%

Depression Is Associated With Constipation in Patients With Parkinson's Disease

Qin

Chen

Lü³

et al. 2020

Front. Neurol.

View full text Add to dashboard Cite

show abstract

“…The hallmark clinical symptom of PD is motor impairment (i.e., rigidity, movement slowness, resting tremor, among others [ 4 , 5 , 6 ]), which is first noticeable when there is already 40–60% neuronal loss in the substantia nigra (SN) [ 7 , 8 ]. However, clinical features include non-motor symptoms such as depression [ 9 ], REM-sleep behavior disorder [ 10 , 11 ], autonomic dysfunction [ 12 ], olfactory disruption [ 13 ], and constipation [ 14 , 15 ], among others. In the past 15 years, non-motor PD symptoms have raised a lot of attention because they can occur years before the onset of motor symptoms [ 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

New Avenues for Parkinson’s Disease Therapeutics: Disease-Modifying Strategies Based on the Gut Microbiota

Lorente-Picón

Laguna

2021

Biomolecules

View full text Add to dashboard Cite

Parkinson’s disease (PD) is a multifactorial neurodegenerative disorder that currently affects 1% of the population over the age of 60 years, and for which no disease-modifying treatments exist. Neurodegeneration and neuropathology in different brain areas are manifested as both motor and non-motor symptoms in patients. Recent interest in the gut–brain axis has led to increasing research into the gut microbiota changes in PD patients and their impact on disease pathophysiology. As evidence is piling up on the effects of gut microbiota in disease development and progression, another front of action has opened up in relation to the potential usage of microbiota-based therapeutic strategies in treating gastrointestinal alterations and possibly also motor symptoms in PD. This review provides status on the different strategies that are in the front line (i.e., antibiotics; probiotics; prebiotics; synbiotics; dietary interventions; fecal microbiota transplantation, live biotherapeutic products), and discusses the opportunities and challenges the field of microbiome research in PD is facing.

show abstract

“…In contrast to emergency ileus in PD, 4,15 no such condition occurs in SSD except for patients under longstanding antidepressive medication. Thus, constipation is regarded the major GI form of SSD 24 . In patients with depression, functional test (urodynamics) often reveals increased bladder sensation, followed by underactive detrusor 18–20 .…”

Section: Discussionmentioning

confidence: 99%

Does Depression Contribute to the Bladder and Bowel Complaint in Parkinson's Disease Patients?

Sakakibara

Ogata

Aiba

et al. 2020

Movement Disord Clin Pract

View full text Add to dashboard Cite

Background The question of whether depression contributes to the bladder and bowel complaint in Parkinson's disease (PD) has not been addressed. Objectives We studied bladder, bowel and sexual symptoms in PD patients with/without depression. Methods We had 267 referred PD patients: age 68.3 ± 7.7 years, 150 men, 117 women. We divided them into those with/without depression and performed the pelvic function questionnaires including bladder, bowel and sexual items; for example, OABSS, IPSS, and a pelvic organ questionnaire). Results The patient age, sex ratio, disease duration, Hoehn‐Yahr motor grade, and cognitive score were not significantly different between the PD with depression (n = 35, 13.1%) and PD without depression (n = 232, 86.9%) groups. Regarding bladder, bowel and sexual complaints, significant difference was noted in constipation (P = 0.000854) and sensation of residual urine (P = 0.04820) items. Conclusions Our PD patients with depression showed significantly more common constipation and sensation of residual urine compared to the patients with PD alone, suggesting that depression contributes to the bladder and bowel complaint in PD patients.

show abstract

Severe Constipation in Parkinson's Disease and in Parkinsonisms: Prevalence and Affecting Factors

Cited by 30 publications

References 39 publications

Depression Is Associated With Constipation in Patients With Parkinson's Disease

Depression Is Associated With Constipation in Patients With Parkinson's Disease

New Avenues for Parkinson’s Disease Therapeutics: Disease-Modifying Strategies Based on the Gut Microbiota

Does Depression Contribute to the Bladder and Bowel Complaint in Parkinson's Disease Patients?

Contact Info

Product

Resources

About